某些慢性炎症性疾病患者血液中的维生素E含量与脂质过氧化反应

Vitamin E content and lipid peroxidation of blood in some chronic inflammatory diseases.

作者信息

Mézes M, Pár A, Bartosiewicz G, Németh J

出版信息

Acta Physiol Hung. 1987;69(1):133-8.

Abstract

Patients suffering from rheumatoid arthritis, spondylosis, coxarthrosis, ankylosing spondylitis, chronic active and chronic alcoholic hepatitis were studied. The plasma vitamin E content remained unchanged. The TBA-reactive plasma substances (malondialdehyde) content of plasma increased in all patients except those with ankylosing spondylitis. Catalase activity of plasma increased in patients of both sexes suffering from rheumatoid arthritis and spondylosis and coxarthrosis, but decreased in the two hepatitis groups. The glutathione-peroxidase activity of RBC (1:9 haemolysate) increased in female rheumatoid arthritis patients and decreased in those suffering from chronic alcoholic hepatitis. The results showed that chronic inflammatory processes affect the rate of lipid peroxidation and the activity of the biological antioxidant mechanism.

摘要

对患有类风湿性关节炎、脊椎病、髋关节炎、强直性脊柱炎、慢性活动性肝炎和慢性酒精性肝炎的患者进行了研究。血浆维生素E含量保持不变。除强直性脊柱炎患者外，所有患者血浆中TBA反应性血浆物质（丙二醛）含量均升高。患有类风湿性关节炎、脊椎病和髋关节炎的男女患者血浆过氧化氢酶活性升高，但在两个肝炎组中降低。红细胞（1:9溶血产物）的谷胱甘肽过氧化物酶活性在女性类风湿性关节炎患者中升高，而在慢性酒精性肝炎患者中降低。结果表明，慢性炎症过程会影响脂质过氧化速率和生物抗氧化机制的活性。