FeCl 催化 1-茚满-1,2,3-三酮与炔烃反应合成丹参酮类似物。
FeCl-Catalyzed Synthesis of Tanshinlactone Analogues from 1-Indene-1,2,3-triones and Alkynes.
机构信息
Department of Chemistry, College of Science, Tianjin University, Tianjin 300350, P. R. China.
Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 30072, P. R. China.
出版信息
J Org Chem. 2022 Aug 19;87(16):10982-10989. doi: 10.1021/acs.joc.2c01254. Epub 2022 Aug 1.
Tanshinlactone has been found in several natural products and biologically active compounds. Herein, a new FeCl-catalyzed strategy using 1-indene-1,2,3-triones and alkynes as starting materials is reported to obtain various tanshinlactone derivatives. This protocol has the advantages of involving low cost, environmentally benign catalysts, simple reaction conditions, and a broad range of substrates.
丹酚酸已在几种天然产物和生物活性化合物中被发现。在此，我们报告了一种新的 FeCl 催化策略，使用 1-茚满-1,2,3-三酮和炔烃作为起始原料来获得各种丹参酮衍生物。该方案具有成本低、环境友好的催化剂、简单的反应条件以及广泛的底物范围等优点。
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