Division of Infectious Diseases, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, CA, USA.
Nat Microbiol. 2022 Aug;7(8):1127-1140. doi: 10.1038/s41564-022-01172-2. Epub 2022 Aug 2.
Coronavirus disease 2019 (COVID-19)-associated invasive fungal infections are an important complication in a substantial number of critically ill, hospitalized patients with COVID-19. Three groups of fungal pathogens cause co-infections in COVID-19: Aspergillus, Mucorales and Candida species, including Candida auris. Here we review the incidence of COVID-19-associated invasive fungal infections caused by these fungi in low-, middle- and high-income countries. By evaluating the epidemiology, clinical risk factors, predisposing features of the host environment and immunological mechanisms that underlie the pathogenesis of these co-infections, we set the scene for future research and development of clinical guidance.
2019 冠状病毒病（COVID-19）相关侵袭性真菌感染是大量重症 COVID-19 住院患者的重要并发症。有三组真菌病原体可导致 COVID-19 的合并感染：曲霉属、毛霉目和念珠菌属，包括耳念珠菌。在此，我们回顾了在低收入、中等收入和高收入国家由这些真菌引起的 COVID-19 相关侵袭性真菌感染的发生率。通过评估这些合并感染的流行病学、临床危险因素、宿主环境的易患特征和免疫发病机制，我们为未来的临床指导研发奠定了基础。
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