Department of Ophthalmology, Tirunelveli Medical College Hospital, Tirunelveli, Tamil Nadu, India.
Research Analyst, Queen Mary's College, Tamil Nadu, India.
Indian J Ophthalmol. 2022 Aug;70(8):3077-3082. doi: 10.4103/ijo.IJO_3017_21.
To describe the etiology, clinical profile, duration of lagophthalmos cases and thereby, framing a decision for the management based on the severity of Exposure keratitis (EK), Facial palsy (FP) with each etiology and to describe the outcome of the management options.
The method was a prospective review of 120 lagophthalmos cases treated at a single tertiary center from January 2018 to January 2019. The main outcome measures were analysing the association between age, etiology, duration and management of lagophthalmos.
Of the 120 patients studied, paralytic etiology was noted in 86 and eyelid etiology in 34 patients. The percentage of various lagophthalmos etiology documented were Bell's palsy (35.83%), lagophthalmos in ICU patients (15%), traumatic facial palsy(FP) (10.80%), stroke associated FP (6.67%), infection associated FP (6.67%), iatrogenic FP, cicatricial lagophthalmos (5%), lagophthalmos post eyelid surgeries (5%), neoplastic FP(3.33%), congenital FP (1.67%), proptosis induced lagophthalmos (1.67%), floppy eyelid syndrome induced lagophthalmos (0.83%) and lid coloboma associated lagophthalmos (0.83%). A statistically significant correlation was noted between exposure keratitis and age, with an increased prevalence age advances. The management showed significant variation with individual etiology, with some etiologies unquestionably requiring surgical management. Surgical management is crucial as the duration of lagophthalmos increases more than 6 weeks, EK involving pupillary axis and poor FP recovery.
This study concludes that the conservative management was sufficient in all cases when the duration is less than 1 week, Exposure keratitis not involving the pupillary axis (EK< Grade II) and FP with good functional recovery ( FP < Grade III). The predominant causes being Bell's palsy, lagophthalmos in ICU patients and vascular FP. Whereas, cases with poor functional recovery of facial palsy(FP) and permanent eyelid deformation require definitive surgical management like Traumatic FP & cicatricial lagophthalmos.
描述眼裂闭合不全的病因、临床特征、闭眼时间,并据此根据暴露性角膜炎(EK)的严重程度、面瘫(FP)的病因制定治疗决策,描述各种治疗选择的结果。
该研究为 2018 年 1 月至 2019 年 1 月在一家三级中心治疗的 120 例眼裂闭合不全患者的前瞻性回顾。主要观察指标为分析年龄、病因、闭眼时间与眼裂闭合不全治疗的相关性。
120 例患者中,麻痹性病因 86 例,眼睑性病因 34 例。记录的各种眼裂闭合不全病因的比例分别为贝尔麻痹(35.83%)、重症监护病房患者的眼裂闭合不全(15%)、创伤性面瘫(10.80%)、中风相关面瘫(6.67%)、感染相关面瘫(6.67%)、医源性面瘫、瘢痕性眼裂闭合不全(5%)、眼睑手术后眼裂闭合不全(5%)、肿瘤相关面瘫(3.33%)、先天性面瘫(1.67%)、眼球突出导致的眼裂闭合不全(1.67%)、眼睑下垂综合征导致的眼裂闭合不全(0.83%)和眼睑裂缺失相关的眼裂闭合不全(0.83%)。暴露性角膜炎与年龄呈显著正相关,随着年龄的增长,发病率逐渐升高。不同病因的治疗方法存在显著差异,有些病因毫无疑问需要手术治疗。当闭眼时间超过 6 周、暴露性角膜炎累及瞳孔轴且面瘫恢复不佳时,手术治疗至关重要。
本研究表明,当闭眼时间小于 1 周、暴露性角膜炎不涉及瞳孔轴(EK<Ⅱ级)且面瘫有良好的功能恢复(FP<Ⅲ级)时,所有病例均采用保守治疗即可。主要病因是贝尔麻痹、重症监护病房患者的眼裂闭合不全和血管性面瘫。而面瘫恢复不佳和永久性眼睑变形的病例需要进行确定性手术治疗,如创伤性面瘫和瘢痕性眼裂闭合不全。