合成及一系列新型双膦基铼（V）双氧配合物的抗菌活性。
Synthesis and anti-microbial activity of a new series of bis(diphosphine) rhenium(V) dioxo complexes.
机构信息
Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, 82 Wood Lane, White City Campus, London, W12 0BZ, UK.
出版信息
Dalton Trans. 2022 Aug 30;51(34):12791-12795. doi: 10.1039/d2dt02157a.
PMID:35920379
Abstract
Rhenium-based metallodrugs have recently been highlighted as promising candidates for new antibiotics to combat multi-drug resistant (MDR) pathogens. A new class of rhenium(V) dioxo complexes were prepared from readily accessible diphosphine ligands, and have been shown to possess potent activity against () and () alongside low human cell toxicity.
摘要
基于铼的金属药物最近被强调为有前途的新型抗生素候选物，以对抗多药耐药（MDR）病原体。一类新型的铼（V）双氧络合物由易于获得的双膦配体制备，并已被证明对（）和（）具有强大的活性，同时对人体细胞的毒性较低。
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