生理和病理血管生成中RNA修饰的研究进展
Research Progress for RNA Modifications in Physiological and Pathological Angiogenesis.
作者信息
Chen Hui-Ming, Li Hang, Lin Meng-Xian, Fan Wei-Jie, Zhang Yi, Lin Yan-Ting, Wu Shu-Xiang
机构信息
Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
Fujian Key Laboratory of Tumor Microbiology, Department of Medical Microbiology, Fujian Medical University, Fuzhou, China.
出版信息
Front Genet. 2022 Jul 22;13:952667. doi: 10.3389/fgene.2022.952667. eCollection 2022.
As a critical layer of epigenetics, RNA modifications demonstrate various molecular functions and participate in numerous biological processes. RNA modifications have been shown to be essential for embryogenesis and stem cell fate. As high-throughput sequencing and antibody technologies advanced by leaps and bounds, the association of RNA modifications with multiple human diseases sparked research enthusiasm; in addition, aberrant RNA modification leads to tumor angiogenesis by regulating angiogenesis-related factors. This review collected recent cutting-edge studies focused on RNA modifications (N-methyladenosine (mA), N-methylcytosine (mC), N-methylguanosine (mG), N-methyladenosine (mA), and pseudopuridine (Ψ)), and their related regulators in tumor angiogenesis to emphasize the role and impact of RNA modifications.
作为表观遗传学的关键层面，RNA修饰展现出多种分子功能并参与众多生物学过程。RNA修饰已被证明对胚胎发育和干细胞命运至关重要。随着高通量测序和抗体技术的飞速发展，RNA修饰与多种人类疾病的关联引发了研究热潮；此外，异常的RNA修饰通过调节血管生成相关因子导致肿瘤血管生成。本综述收集了近期聚焦于RNA修饰（N-甲基腺苷（mA）、N-甲基胞嘧啶（mC）、N-甲基鸟苷（mG）、N-甲基腺苷（mA）和假尿苷（Ψ））及其在肿瘤血管生成中的相关调节因子的前沿研究，以强调RNA修饰的作用和影响。
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