Noise Characteristics Modeled Unsupervised Network for Robust CT Image Reconstruction.

Deep learning (DL)-based methods show great potential in computed tomography (CT) imaging field. The DL-based reconstruction methods are usually evaluated on the training and testing datasets which are obtained from the same distribution, i.e., the same CT scan protocol (i.e., the region setting, kVp, mAs, etc.). In this work, we focus on analyzing the robustness of the DL-based methods against protocol-specific distribution shifts (i.e., the training and testing datasets are from different region settings, different kVp settings, or different mAs settings, respectively). The results show that the DL-based reconstruction methods are sensitive to the protocol-specific perturbations which can be attributed to the noise distribution shift between the training and testing datasets. Based on these findings, we presented a low-dose CT reconstruction method using an unsupervised strategy with the consideration of noise distribution to address the issue of protocol-specific perturbations. Specifically, unpaired sinogram data is enrolled into the network training, which represents unique information for specific imaging protocol, and a Gaussian mixture model (GMM) is introduced to characterize the noise distribution in CT images. It can be termed as GMM based unsupervised CT reconstruction network (GMM-unNet) method. Moreover, an expectation-maximization algorithm is designed to optimize the presented GMM-unNet method. Extensive experiments are performed on three datasets from different scan protocols, which demonstrate that the presented GMM-unNet method outperforms the competing methods both qualitatively and quantitatively.