韩国人群中γ-谷氨酰转移酶与头颈部癌症的相关性：一项全国人群为基础的研究。

Association between γ-Glutamyltransferase and Head and Neck Cancer in Korean Population: A National Population-Based Study.

机构信息

Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Department of Otorhinolaryngology-Head and Neck Surgery, Chung-Ang University, College of Medicine, Gwangmyeong Hospital, Seoul, Republic of Korea.

出版信息

Cancer Epidemiol Biomarkers Prev. 2022 Oct 4;31(10):1975-1982. doi: 10.1158/1055-9965.EPI-22-0401.

DOI:10.1158/1055-9965.EPI-22-0401

PMID:35944063

Abstract

BACKGROUND

Gamma-glutamyltransferase (GGT) is positively associated with several cancer types. The objective of this study was to investigate the association between GGT and head and neck cancer (HNC) incidence in a cohort of 10 million people, considering effects of smoking and alcohol consumption.

METHODS

All data used in this study were obtained from the Korean National Health Insurance Service database. We analyzed subjects who underwent health check-ups in 2009 and monitored them until 2018 (n = 9,597,952). Using proportional hazards models, quartiles of GGT as independent predictors for HNC incidence were evaluated.

RESULTS

The overall incidence of HNC increased in the highest quartile [r-GPT ≥ 40 U/L; HR, 1.452; 95% confidence interval (CI), 1.354-1.557]. Among HNC cases, the HR for hypopharyngeal cancer (HR, 2.364; 95% CI, 1.818-3.074) was significantly higher. HRs for HNC (larynx, sino-nasal, oropharynx, oral cavity, and nasopharynx, except salivary glands) were also significant.

CONCLUSIONS

Elevated GGT was associated with the risk of some types of HNCs, such as hypopharyngeal, laryngeal, sinonasal, oropharyngeal, oral cavity, and nasopharyngeal cancer.

IMPACT

Results of this study have implications for etiologic investigations and preventive strategies.

摘要

背景

γ-谷氨酰转移酶（GGT）与多种癌症类型呈正相关。本研究旨在调查在考虑吸烟和饮酒影响的情况下，队列中 1000 万人的 GGT 与头颈部癌症（HNC）发病率之间的关系。

方法

本研究中使用的数据均来自韩国国家健康保险服务数据库。我们分析了 2009 年接受健康检查并在 2018 年之前进行监测的对象（n = 9,597,952）。使用比例风险模型，将 GGT 的四分位数作为 HNC 发病率的独立预测因子进行评估。

结果

HNC 的总体发病率在最高四分位数（r-GPT≥40 U/L；HR，1.452；95%置信区间[CI]，1.354-1.557）中增加。在 HNC 病例中，下咽癌的 HR 更高（HR，2.364；95%CI，1.818-3.074）。HNC（喉、鼻窦、口咽、口腔和鼻咽，除外唾液腺）的 HR 也具有统计学意义。