Adlhoch Cornelia, Fusaro Alice, Gonzales José L, Kuiken Thijs, Marangon Stefano, Niqueux Éric, Staubach Christoph, Terregino Calogero, Aznar Inma, Guajardo Irene Muñoz, Baldinelli Francesca
EFSA J. 2022 Aug 6;20(8):e07415. doi: 10.2903/j.efsa.2022.7415. eCollection 2022 Aug.
The 2021-2022 highly pathogenic avian influenza (HPAI) epidemic season is the largest epidemic so far observed in Europe, with a total of 2,398 outbreaks in poultry, 46 million birds culled in the affected establishments, 168 detections in captive birds, and 2,733 HPAI events in wild birds in 36 European countries. Between 16 March and 10 June 2022, 1,182 HPAI virus detections were reported in 28 EU/EEA countries and United Kingdom in poultry (750), and in wild (410) and captive birds (22). During this reporting period, 86% of the poultry outbreaks were secondary due to between-farm spread of HPAI virus. France accounted for 68% of the overall poultry outbreaks, Hungary for 24% and all other affected countries for less than 2% each. Most detections in wild birds were reported by Germany (158), followed by the Netherlands (98) and the United Kingdom (48). The observed persistence of HPAI (H5) virus in wild birds since the 2020-2021 epidemic wave indicates that it may have become endemic in wild bird populations in Europe, implying that the health risk from HPAI A(H5) for poultry, humans, and wildlife in Europe remains present year-round, with the highest risk in the autumn and winter months. Response options to this new epidemiological situation include the definition and the rapid implementation of suitable and sustainable HPAI mitigation strategies such as appropriate biosecurity measures and surveillance strategies for early detection measures in the different poultry production systems. Medium to long-term strategies for reducing poultry density in high-risk areas should also be considered. The results of the genetic analysis indicate that the viruses currently circulating in Europe belong to clade 2.3.4.4b. HPAI A(H5) viruses were also detected in wild mammal species in Canada, USA and Japan, and showed genetic markers of adaptation to replication in mammals. Since the last report, four A(H5N6), two A(H9N2) and two A(H3N8) human infections were reported in China and one A(H5N1) in USA. The risk of infection is assessed as low for the general population in the EU/EEA, and low to medium for occupationally exposed people.
2021 - 2022年高致病性禽流感(HPAI)流行季是欧洲迄今观测到的最大规模疫情,在36个欧洲国家,家禽中共发生2398起疫情,受影响养殖场扑杀了4600万只禽鸟,圈养鸟类中有168起检测出感染,野生鸟类中有2733起HPAI事件。2022年3月16日至6月10日期间,在28个欧盟/欧洲经济区国家和英国,在家禽(750起)、野生(410起)和圈养鸟类(22起)中报告了1182起HPAI病毒检测结果。在此报告期内,86%的家禽疫情是HPAI病毒在农场间传播导致的继发疫情。法国占家禽疫情总数的68%,匈牙利占24%,其他所有受影响国家各占不到2%。野生鸟类中的多数检测结果由德国报告(158起),其次是荷兰(98起)和英国(48起)。自2020 - 2021年疫情波以来,HPAI(H5)病毒在野生鸟类中持续存在,这表明它可能已在欧洲野生鸟类种群中成为地方病,这意味着欧洲HPAI A(H5)对家禽、人类和野生动物的健康风险全年都存在,在秋冬季节风险最高。针对这一新的流行病学情况的应对选项包括定义并迅速实施适当且可持续的HPAI缓解策略,如在不同家禽生产系统中采取适当的生物安全措施和早期检测措施的监测策略。还应考虑在高风险地区降低家禽密度的中长期策略。基因分析结果表明,目前在欧洲传播的病毒属于2.3.4.4b分支。在加拿大、美国和日本的野生哺乳动物物种中也检测到了HPAI A(H5)病毒,并且显示出适应在哺乳动物中复制的基因标记。自上次报告以来,中国报告了4起A(H5N6)、2起A(H9N2)和2起A(H3N8)人类感染病例,美国报告了1起A(H5N1)人类感染病例。欧盟/欧洲经济区普通人群的感染风险评估为低,职业暴露人群的感染风险评估为低至中。