非编码 RNA 在口腔炎症性疾病和神经病理性疼痛中的临床研究进展：综述

Clinical Perspectives of Non-Coding RNA in Oral Inflammatory Diseases and Neuropathic Pain: A Narrative Review.

机构信息

Department of Pharmacology in Dentistry, School of Dental Medicine, University of Belgrade, 11000 Belgrade, Serbia.

Department of Radiobiology and Molecular Genetics, Vinča Institute of Nuclear Sciences, National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.

出版信息

Int J Mol Sci. 2022 Jul 27;23(15):8278. doi: 10.3390/ijms23158278.

DOI:10.3390/ijms23158278

PMID:35955417

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9368403/

Abstract

Non-coding RNAs (ncRNAs) represent a research hotspot by playing a key role in epigenetic and transcriptional regulation of diverse biological functions and due to their involvement in different diseases, including oral inflammatory diseases. Based on ncRNAs' suitability for salivary biomarkers and their involvement in neuropathic pain and tissue regeneration signaling pathways, the present narrative review aims to highlight the potential clinical applications of ncRNAs in oral inflammatory diseases, with an emphasis on salivary diagnostics, regenerative dentistry, and precision medicine for neuropathic orofacial pain.

摘要

非编码 RNA（ncRNA）通过在不同生物学功能的表观遗传和转录调控中发挥关键作用，成为研究热点，并且由于其参与多种疾病，包括口腔炎症性疾病。基于 ncRNA 适用于唾液生物标志物及其在神经病理性疼痛和组织再生信号通路中的参与，本综述旨在强调 ncRNA 在口腔炎症性疾病中的潜在临床应用，重点是唾液诊断、再生牙科和神经病理性口腔疼痛的精准医学。