α-2b干扰素辅助治疗结膜黑色素瘤
Adjunctive Treatment with Interferon Alpha 2b in Conjunctival Melanoma.
作者信息
Huerva Valentín, Cid-Bertomeu Pau, Espinet Ramón, Canto Luisa M
机构信息
Department of Ophthalmology, Universitary Hospital Arnau de Vilanova, Lleida, Spain.
School of Medicine, Biomedical Research Institute of Lleida, IRB Lleida, University of Lleida, Lleida, Spain.
出版信息
Ocul Oncol Pathol. 2022 Jun;8(2):88-92. doi: 10.1159/000522195. Epub 2022 Jan 27.
PURPOSE
The aim of the study was to demonstrate the clinical outcomes after resection of conjunctival melanoma (CM) followed by topical interferon (IFN) alpha 2b after a long follow-up.
METHODS
Two consecutive CM patients were treated using tumor excision followed by topical IFN alpha 2b (1,000,000 UI/mL) four times a day for 12 weeks. The second case presented positivity due to the presence of tumor cells in the lower margin of the resection. TNM staging was T1c, N0b, M0, and T1b in the first case and T1b, N0b, M0 in the second case. Follow-up was 72 and 71 months, respectively.
RESULTS
No side effects were observable after the administration of topical IFN alpha 2b. After extensive evaluation and imaging with computed tomography, no regrowth or distant metastasis was noticed during the follow-up period in both cases.
CONCLUSIONS
IFN alpha 2b could be used as a co-adjuvant treatment after CM resection, in an attempt to reduce the possibility of recurrences.
目的
本研究的目的是在长期随访后，证明结膜黑色素瘤（CM）切除术后局部应用干扰素（IFN）α-2b的临床疗效。
方法
连续两名CM患者接受肿瘤切除治疗，随后局部应用IFNα-2b（1,000,000 UI/mL），每天4次，持续12周。第二例因切除边缘下部存在肿瘤细胞而呈阳性。第一例患者的TNM分期为T1c、N0b、M0，第二例为T1b、N0b、M0。随访时间分别为72个月和71个月。
结果
局部应用IFNα-2b后未观察到副作用。在进行计算机断层扫描的广泛评估和成像后，两例患者在随访期间均未发现肿瘤复发或远处转移。
结论
IFNα-2b可作为CM切除术后的辅助治疗，以降低复发的可能性。
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