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衰老通过肠道微生物群对急性胰腺炎的影响。

Effect of aging on acute pancreatitis through gut microbiota.

作者信息

Jing Hui, Chang Qimeng, Xu Yayun, Wang Jianfa, Wu Xubo, Huang Jiating, Wang Lishun, Zhang Ziping

机构信息

Department of Hepatopancreatobiliary Surgery, Minhang Hospital, Fudan University, Shanghai, China.

Institute of Fudan-Minhang Academic Health System, Minhang Hospital, Fudan University, Shanghai, China.

出版信息

Front Microbiol. 2022 Jul 28;13:897992. doi: 10.3389/fmicb.2022.897992. eCollection 2022.

DOI:10.3389/fmicb.2022.897992
PMID:35966681
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9366017/
Abstract

BACKGROUND

Compared to younger people, older people have a higher risk and poorer prognosis of acute pancreatitis, but the effect of gut microbiota on acute pancreatitis is still unknown. We aim to investigate the effect of aging gut microbiota on acute pancreatitis and explore the potential mechanism of this phenomenon.

METHODS

Eighteen fecal samples from healthy adult participants, including nine older and nine younger adults were collected. C57BL/6 mice were treated with antibiotics for fecal microbiota transplantation from older and younger participants. Acute pancreatitis was induced by cerulein and lipopolysaccharide in these mice. The effect of the aged gut microbiota was further tested antibiotic treatment before or after acute pancreatitis induction.

RESULTS

The gut microbiota of older and younger adults differed greatly. Aged gut microbiota exacerbated acute pancreatitis during both the early and recovery stages. At the same time, the mRNA expression of multiple antimicrobial peptides in the pancreas and ileum declined in the older group. Antibiotic treatment before acute pancreatitis could remove the effect of aging gut microbiota, but antibiotic treatment after acute pancreatitis could not.

CONCLUSION

Aging can affect acute pancreatitis through gut microbiota which characterizes the deletion of multiple types of non-dominant species. This change in gut microbiota may potentially regulate antimicrobial peptides in the early and recovery stages. The level of antimicrobial peptides has negative correlations with a more severe phenotype.

摘要

背景

与年轻人相比，老年人患急性胰腺炎的风险更高且预后更差，但肠道微生物群对急性胰腺炎的影响仍不清楚。我们旨在研究衰老的肠道微生物群对急性胰腺炎的影响，并探索这一现象的潜在机制。

方法

收集了18份来自健康成年参与者的粪便样本，其中包括9名老年人和9名年轻人。对C57BL/6小鼠进行抗生素处理，以进行来自老年和年轻参与者的粪便微生物群移植。在这些小鼠中通过雨蛙肽和脂多糖诱导急性胰腺炎。在急性胰腺炎诱导之前或之后进行抗生素处理，进一步测试衰老肠道微生物群的作用。

结果

老年人和年轻人的肠道微生物群差异很大。衰老的肠道微生物群在急性胰腺炎的早期和恢复阶段均会加剧病情。同时，老年组胰腺和回肠中多种抗菌肽的mRNA表达下降。急性胰腺炎之前进行抗生素处理可以消除衰老肠道微生物群的影响，但急性胰腺炎之后进行抗生素处理则无法消除。

结论

衰老可通过肠道微生物群影响急性胰腺炎，其特征是多种非优势菌种的缺失。肠道微生物群的这种变化可能在早期和恢复阶段潜在地调节抗菌肽。抗菌肽水平与更严重的表型呈负相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a885/9366017/3162ea27d1e0/fmicb-13-897992-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a885/9366017/15a01e2f8ea1/fmicb-13-897992-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a885/9366017/242bcaef87a6/fmicb-13-897992-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a885/9366017/59b479219053/fmicb-13-897992-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a885/9366017/31d80f8c9437/fmicb-13-897992-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a885/9366017/aa71a1ab55ef/fmicb-13-897992-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a885/9366017/bd9f479dba4c/fmicb-13-897992-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a885/9366017/23ebb68db532/fmicb-13-897992-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a885/9366017/3162ea27d1e0/fmicb-13-897992-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a885/9366017/15a01e2f8ea1/fmicb-13-897992-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a885/9366017/242bcaef87a6/fmicb-13-897992-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a885/9366017/59b479219053/fmicb-13-897992-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a885/9366017/31d80f8c9437/fmicb-13-897992-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a885/9366017/aa71a1ab55ef/fmicb-13-897992-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a885/9366017/bd9f479dba4c/fmicb-13-897992-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a885/9366017/23ebb68db532/fmicb-13-897992-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a885/9366017/3162ea27d1e0/fmicb-13-897992-g008.jpg

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The Drosophila Baramicin polypeptide gene protects against fungal infection.果蝇巴氨基多肽基因可抵御真菌感染。
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