Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, China.
Xiangya School of Medicine, Central South University, Changsha, China.
Front Cell Infect Microbiol. 2022 Jul 28;12:945956. doi: 10.3389/fcimb.2022.945956. eCollection 2022.
The persistence of latent reservoir of the human immunodeficiency virus (HIV) is currently the major challenge in curing HIV infection. After HIV infects the human body, the latent HIV is unable to be recognized by the body's immune system. Currently, the widely adopted antiretroviral therapy (ART) is also unble to eliminate it, thus hindering the progress of HIV treatment. This review discusses the existence of latent HIV vault for HIV treatment, its formation and factors affecting its formation, cell, and tissue localization, methods for detection and removing latent reservoir, to provide a comprehensive understanding of latent HIV vault, in order to assist in the future research and play a potential role in achieving HIV treatment.
潜伏的人类免疫缺陷病毒 (HIV) 库的持续存在是治愈 HIV 感染的主要挑战。HIV 感染人体后，潜伏的 HIV 无法被人体免疫系统识别。目前，广泛采用的抗逆转录病毒疗法 (ART) 也无法消除它，从而阻碍了 HIV 治疗的进展。本综述讨论了潜伏 HIV 库在 HIV 治疗中的存在、其形成以及影响其形成的因素、细胞和组织定位、检测和清除潜伏库的方法，为全面了解潜伏 HIV 库提供帮助，以期为未来的研究提供帮助，并在实现 HIV 治疗方面发挥潜在作用。
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