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南亚家畜基因组学的发展轨迹:综述

Trajectory of livestock genomics in South Asia: A comprehensive review.

机构信息

Division of Animal Genetics, Indian Veterinary Research Institute, Izatnagar, Bareilly 243122, UP, India.

Division of Animal Genetics, Indian Veterinary Research Institute, Izatnagar, Bareilly 243122, UP, India.

出版信息

Gene. 2022 Nov 15;843:146808. doi: 10.1016/j.gene.2022.146808. Epub 2022 Aug 13.

Abstract

Livestock plays a central role in sustaining human livelihood in South Asia. There are numerous and distinct livestock species in South Asian countries. Several of them have experienced genetic development in recent years due to the application of genomic technologies and effective breeding programs. This review discusses genomic studies on cattle, buffalo, sheep, goat, pig, horse, camel, yak, mithun, and poultry. The frontiers covered in this review are genetic diversity, admixture studies, selection signature research, QTL discovery, genome-wide association studies (GWAS), and genomic selection. The review concludes with recommendations for South Asian livestock systems to increasingly leverage genomic technologies, based on the lessons learned from the numerous case studies. This paper aims to present a comprehensive analysis of the dichotomy in the South Asian livestock sector and argues that a realistic approach to genomics in livestock can ensure long-term genetic advancements.

摘要

家畜在维持南亚人类生计方面发挥着核心作用。南亚国家有许多不同的家畜物种。由于基因组技术和有效的繁育计划的应用,近年来其中一些物种经历了遗传发展。本综述讨论了关于牛、水牛、绵羊、山羊、猪、马、骆驼、牦牛、野牛和家禽的基因组研究。本综述涵盖的前沿领域包括遗传多样性、混合研究、选择特征研究、QTL 发现、全基因组关联研究(GWAS)和基因组选择。综述最后根据从众多案例研究中吸取的经验教训,为南亚家畜系统提出了更多利用基因组技术的建议。本文旨在对南亚家畜部门的二分法进行全面分析,并认为对家畜基因组学采取现实的方法可以确保长期的遗传进步。

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