回忆疗法作为改善老年肝细胞癌患者心理健康和生活质量的潜在方法：一项随机对照试验

Reminiscence Therapy as a Potential Method to Improve Psychological Health and Quality of Life in Elderly Hepatocellular Carcinoma Patients: A Randomized, Controlled Trial.

作者信息

Li Teng, Li Bin, Tan Lu, Lv Bo

机构信息

Department of Hepatobiliary and Pancreatic Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

出版信息

Front Surg. 2022 Aug 2;9:873843. doi: 10.3389/fsurg.2022.873843. eCollection 2022.

BACKGROUND

Reminiscence therapy mitigates psychological issues and improves the quality of life of cancer survivors. However, its role in elderly patients with hepatocellular carcinoma (HCC) is unclear. Thus, we aimed to detect the effect of reminiscence therapy on anxiety, depression, and the quality of life of elderly patients with HCC.

METHODS

In total, 106 elderly patients with HCC after resection were randomized in a 1:1 ratio to the reminiscence therapy group ( = 54) and control care group ( = 52) and then received intervention for 12 months. Anxiety and depression were evaluated by the Hospital Anxiety and Depression Scale (HADS) at baseline [Month (M) 0], 3 months (M3), 6 months (M6), 9 months (M9), and 12 months (M12). Meanwhile, quality of life was assessed using the European Organization for Research and Treatment of Cancer quality of life Questionnaire-Core 30 (QLQ-C30) at M0, M6, and M12.

RESULTS

The HADS for anxiety score at M9 (6.8 ± 2.3 vs. 7.8 ± 2.4, = 0.039) and M12 (6.6 ± 2.4 vs. 7.8 ± 2.6, = 0.013) and the anxiety proportion at M12 (27.8% vs. 46.2%, = 0.050) were reduced in the reminiscence therapy group compared with those in the control care group. Moreover, the HADS for depression score declined at M9 (6.6 ± 2.0 vs. 7.5 ± 2.2, = 0.025) and M12 (6.3 ± 2.3 vs. 7.7 ± 2.6, = 0.005), but the proportion of those with depression was not different at each visit ( > 0.05) in the reminiscence therapy group compared with that of the control care group. In addition, the QLQ-C30 global health status score increased at M6 (71.3 ± 12.8 vs. 66.3 ± 12.9, = 0.048) and M12 (74.5 ± 12.9 vs. 68.2 ± 13.3, = 0.014) in the reminiscence therapy group compared to that in the control care group.

CONCLUSION

Reminiscence therapy effectively mitigates anxiety and depression and improves the quality of life of elderly patients with HCC.

背景

回忆疗法可减轻心理问题并提高癌症幸存者的生活质量。然而，其在老年肝细胞癌（HCC）患者中的作用尚不清楚。因此，我们旨在检测回忆疗法对老年HCC患者焦虑、抑郁及生活质量的影响。

方法

总共106例HCC切除术后的老年患者按1:1比例随机分为回忆疗法组（n = 54）和对照护理组（n = 52），然后接受为期12个月的干预。在基线[第0个月（M0）]、3个月（M3）、6个月（M6）、9个月（M9）和12个月（M12）时，采用医院焦虑抑郁量表（HADS）评估焦虑和抑郁情况。同时，在M0、M6和M12时，使用欧洲癌症研究与治疗组织生活质量核心问卷30（QLQ - C30）评估生活质量。

结果

与对照护理组相比，回忆疗法组在M9时的HADS焦虑评分（6.8±2.3 vs. 7.8±2.4，P = 0.039）和M12时的评分（6.6±2.4 vs. 7.8±2.6，P = 0.013）以及M12时的焦虑比例（27.8% vs. 46.2%，P = 0.050）均降低。此外，回忆疗法组在M9时的HADS抑郁评分下降（6.6±2.0 vs. 7.5±2.2，P = 0.025），M12时也下降（6.3±2.3 vs. 7.7±2.6，P = 0.005），但与对照护理组相比，回忆疗法组每次访视时的抑郁比例无差异（P>0.05）。另外，与对照护理组相比，回忆疗法组在M6时的QLQ - C30总体健康状况评分升高（71.3±12.8 vs.