COVID-19 病引起的氧化应激和临床实验室参数在中度和重度患者中的改变。

COVID-19 disease induced alteration of oxidative stress and clinical laboratory parameters in moderate and severe patients.

机构信息

Institute of Preclinical and Clinical Pharmacology and Toxicology, University of Ss Cyril and Methodius, Faculty of Medicine, Skopje, Republic of North Macedonia.

出版信息

Eur Rev Med Pharmacol Sci. 2022 Aug;26(15):5611-5617. doi: 10.26355/eurrev_202208_29434.

DOI:10.26355/eurrev_202208_29434

PMID:35993660

Abstract

OBJECTIVE

The aim of our study was to present the clinical alterations of CRP, LDH, neutrophil to lymphocyte ratio, platelets to lymphocyte ratio, D-dimer, blood gas analyses, vitamin D, VEGF, IL-6, IFN-γ, CD4+, CD8+) and their correlation with oxidative stress index (OSI) in hospitalized COVID-19 patients.

PATIENTS AND METHODS

Oxidative stress index and clinical parameters were determined at admission and/or 7 days after hospitalization in 50 patients divided in moderate and severe group.

RESULTS

In the moderate group of patients, a good correlation (R2 = 0.7400, p<0.05) was found between OSI and PLR, D-dimers and LDH at admission and after 7 days. The OSI correlated well with vitamin D, INF-γ, IL-6, CD4+, CD8+ and the absolute CD8 cell number on admission (R2=0.7635, p<0.05). Vitamin D deficiency (15.37 ng/mL ± 2.81) was observed at admission in the severe group, accompanied by increased levels of IL-6 (295.3 pg/mL ± 40.06), INF-γ (1.603 pg/mL ± 0.134), VEGF (546.8 pg/mL ± 124.2) compared to non-infected individuals. All patients had low partial pressure of oxygen, although it did not show statistically significant difference between the two groups.

CONCLUSIONS

All investigated parameters were altered in both groups of patients and a good correlation between them was demonstrated.

摘要

目的

本研究旨在展示 COVID-19 住院患者 C 反应蛋白（CRP）、乳酸脱氢酶（LDH）、中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、D-二聚体、血气分析、维生素 D、血管内皮生长因子（VEGF）、白细胞介素 6（IL-6）、干扰素-γ（IFN-γ）、CD4+、CD8+的临床变化及其与氧化应激指数（OSI）的相关性。

患者和方法

在 50 名患者中，分别在入院时和/或入院后 7 天测定氧化应激指数和临床参数，并将其分为中度和重度组。

结果

在中度组患者中，OSI 与入院时和入院后 7 天的 PLR、D-二聚体和 LDH 之间存在良好的相关性（R2=0.7400，p<0.05）。OSI 与入院时的维生素 D、IFN-γ、IL-6、CD4+、CD8+和绝对 CD8 细胞数呈良好相关性（R2=0.7635，p<0.05）。入院时，严重组患者维生素 D 缺乏（15.37ng/mL±2.81），伴有 IL-6（295.3pg/mL±40.06）、IFN-γ（1.603pg/mL±0.134）、VEGF（546.8pg/mL±124.2）水平升高，与未感染者相比。所有患者的氧分压均较低，尽管两组之间无统计学差异。