前额皮质作为觉醒回路的关键节点。
Prefrontal cortex as a key node in arousal circuitry.
机构信息
Department of Anesthesiology, University of Michigan, Ann Arbor, MI, USA; Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA; Center for Consciousness Science, University of Michigan, Ann Arbor, MI, USA; Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA.
Department of Anesthesiology, University of Michigan, Ann Arbor, MI, USA; Center for Consciousness Science, University of Michigan, Ann Arbor, MI, USA; Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
出版信息
Trends Neurosci. 2022 Oct;45(10):722-732. doi: 10.1016/j.tins.2022.07.002. Epub 2022 Aug 19.
The role of the prefrontal cortex (PFC) in the mechanism of consciousness is a matter of active debate. Most theoretical and empirical investigations have focused on whether the PFC is critical for the content of consciousness (i.e., the qualitative aspects of conscious experience). However, there is emerging evidence that, in addition to its well-established roles in cognition, the PFC is a key regulator of the level of consciousness (i.e., the global state of arousal). In this opinion article we review recent data supporting the hypothesis that the medial PFC is a critical node in arousal-promoting networks.
前额叶皮层（PFC）在意识机制中的作用是一个活跃的争论点。大多数理论和实证研究都集中在 PFC 是否对意识的内容（即意识体验的定性方面）至关重要。然而，有新的证据表明，除了在认知中的既定作用外，PFC 还是意识水平（即整体觉醒状态）的关键调节者。在这篇观点文章中，我们回顾了支持内侧前额叶皮层是促进觉醒网络关键节点这一假说的最新数据。
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