牙髓组织中缺氧依赖性血管生成过程。
The hypoxia-dependent angiogenic process in dental pulp.
机构信息
Unidad de Terapia Celular - Centro de Medicina Regenerativa, Instituto Venezolano de Investigaciones Científicas (IVIC), Caracas, Venezuela.
Unidad de Terapia Celular - Centro de Medicina Regenerativa, Instituto Venezolano de Investigaciones Científicas (IVIC), Caracas, Venezuela.
出版信息
J Oral Biosci. 2022 Dec;64(4):381-391. doi: 10.1016/j.job.2022.08.004. Epub 2022 Aug 23.
BACKGROUND
In this review, we analyzed the existing literature to elucidate how the hypoxia-dependent angiogenic processes work in dental pulp. Angiogenesis is an essential biological process in the maturation and homeostasis of teeth. It involves multiple sequential steps such as endothelial cell proliferation and migration, cell-to-cell contact, and tube formation.
HIGHLIGHT
Clinical implications of understanding the process of angiogenesis include how the mineralization processes of dental pulp occur and how dental pulp maintains its homeostasis, preventing irreversible inflammation or necrosis.
CONCLUSION
The angiogenesis process in dental pulp regulates adequate concentrations of oxygen required for mineralization in root development and defense mechanisms against chronic stimuli.
背景
在这篇综述中，我们分析了现有文献，以阐明缺氧依赖性血管生成过程在牙髓中的作用。血管生成是牙齿成熟和稳态的一个重要生物学过程。它涉及多个连续的步骤，如内皮细胞的增殖和迁移、细胞间的接触和管形成。
亮点
了解血管生成过程的临床意义包括牙髓的矿化过程是如何发生的，以及牙髓如何维持其稳态，防止不可逆的炎症或坏死。
结论
牙髓中的血管生成过程调节了根发育中矿化所需的氧气浓度，并对慢性刺激产生防御机制。
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