颅内容积是否为 IDH 突变型低级别胶质瘤的危险因素？一项病例对照研究。
Is intracranial volume a risk factor for IDH-mutant low-grade glioma? A case-control study.
机构信息
Department of Neurosurgery, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.
出版信息
J Neurooncol. 2022 Oct;160(1):101-106. doi: 10.1007/s11060-022-04120-6. Epub 2022 Aug 27.
PURPOSE
Risk of cancer has been associated with body or organ size in several studies. We sought to investigate the relationship between intracranial volume (ICV) (as a proxy for lifetime maximum brain size) and risk of IDH-mutant low-grade glioma.
METHODS
In a multicenter case-control study based on population-based data, we included 154 patients with IDH-mutant WHO grade 2 glioma and 995 healthy controls. ICV in both groups was calculated from 3D MRI brain scans using an automated reverse brain mask method, and then compared using a binomial logistic regression model.
RESULTS
We found a non-linear association between ICV and risk of glioma with increasing risk above and below a threshold of 1394 ml (p < 0.001). After adjusting for ICV, sex was not a risk factor for glioma.
CONCLUSION
Intracranial volume may be a risk factor for IDH-mutant low-grade glioma, but the relationship seems to be non-linear with increased risk both above and below a threshold in intracranial volume.
目的
在几项研究中，身体或器官大小与癌症风险相关。我们试图调查颅内体积（ICV）（作为一生中大脑最大尺寸的代表）与 IDH 突变型低级别胶质瘤风险之间的关系。
方法
在一项基于人群数据的多中心病例对照研究中，我们纳入了 154 名 IDH 突变型 WHO 2 级胶质瘤患者和 995 名健康对照者。两组的 ICV 均使用自动反向脑掩模方法从 3D MRI 脑扫描中计算得出，并使用二项逻辑回归模型进行比较。
结果
我们发现 ICV 与胶质瘤风险之间存在非线性关联，在阈值 1394ml 以上和以下时风险均增加（p<0.001）。在校正了 ICV 后，性别不是胶质瘤的危险因素。
结论
颅内体积可能是 IDH 突变型低级别胶质瘤的一个危险因素，但这种关系似乎是非线性的，在颅内体积的阈值上下都有增加的风险。
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