Epidemiology, Serotype and Resistance of Isolates from a Children's Hospital in Hangzhou, Zhejiang, China, 2006-2021.

PURPOSE

This research investigated the dynamics of antibiotic resistance in and the epidemiology of infection in children. These data can aid in the prevention and control of the epidemic and the diagnosis and treatment of salmonellosis.

METHODS

In this study, we retrospectively reviewed and analysed data regarding epidemiology, clinical symptoms, serotypes, and antibiotic resistance from the medical records of patients with infections in Hangzhou Children's Hospital from April 2006 to December 2021.

RESULTS

A total of 2099 isolates were identified during the 16-year study period, and 98.6% (2069) of the isolates were isolated from stool. About 84.5% (1773/2099) of the total isolates were detected from May to October. The median age of the 2099 children with infection was 1.4 years (17 months) (IQR: 0.9-2.8 years). In 1572 (74.9%) patients, the course of the disease was limited to uncomplicated gastroenteritis. (805/2099, 38.4%) was predominant, followed by (290/2099, 13.8%). The total number of serotypes and the number of less common serotypes are increasing. Nontyphoid that cause invasive infections, including , and , accounted for 60.0% (18/30). The strains were resistant to ampicillin, ampicillin-sulbactam, trimethoprim-sulfamethoxazole, ceftriaxone, and ciprofloxacin at percentages of 71.5%, 51.5%, 36.5%, 22.4%, and 14.7%, respectively. No imipenem-resistant strains were identified. 24.8% of the isolates exhibited multidrug resistance (MDR).

CONCLUSION

and were the dominant serotypes in children (<2 years) with -infected arrhoea in Hangzhou, China. Ongoing serotype monitoring should be necessitated and dynamic changes in serotypes should be carefully examined to prevent the sudden outbreak of foodborne illness. exhibits a higher rate of resistance to common antibiotics, and the risk of multidrug resistance should not be ignored. Therefore, clinicians should administer antibiotics judiciously according to the results of drug sensitivity tests.