确定电离过氧化氢消毒的有效性。
Determining the Effectiveness of Decontamination with Ionized Hydrogen Peroxide.
作者信息
Grimaldo Miguel A, Bouyer Donald H, de Siqueira Claudio L Mafra
机构信息
Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brasil.
University of Texas Medical Branch, Galveston, TX, USA.
出版信息
Appl Biosaf. 2020 Sep 1;25(3):134-141. doi: 10.1177/1535676020935405.
INTRODUCTION
Ionized Hydrogen Peroxide (iHP) is a new technology used for the decontamination of surfaces or laboratory areas. It utilizes a low concentration of hydrogen peroxide (HO) mixed with air and ionized through a cold plasma arc. This technology generates reactive oxygen species (ROS) as a means of decontamination.
OBJECTIVES
The purpose of this study is to evaluate the diffusion effect of iHP and its decontamination capabilities using biological and enzyme indicators.
METHODS
A gas-tight fumigation room with a volume of 880 ft was used for the decontamination trials. During the decontamination process, empty animal cages were placed inside to create fumigant distribution restrictions. Spore and enzyme indicators were placed in eleven locations throughout the decontamination room. Generation of iHP was done with the use of TOMI's SteraMist Environmental System and the SteraMist Solution, with 7.8% HO at a dose of 0.5 ml per ft.
RESULTS
For the decontamination of 1hr, 2hrs, 6hrs, and 12hrs, the biological indicators of in Stainless Steel (SS) Disk in Tyvek envelope have an inactivation rate of 94%, 97%, 100%, and 100%, respectively. For . in SS disk and Tyvek envelope, it has 82%, 68%, 100%, and 100%, respectively and, for . in SS strips it has an effective rate of 88%, 67%, 91%, and 100%, respectively.
CONCLUSION
iHP inactivates spores, and the residual tAK activity indicates a gas-like fumigant diffusion due to the uniformity of the inactivation without the use of oscillating fans as the contact time is extended.
引言
电离过氧化氢（iHP）是一种用于表面或实验室区域去污的新技术。它利用低浓度的过氧化氢（HO）与空气混合，并通过冷等离子弧进行电离。该技术通过产生活性氧（ROS）来实现去污。
目的
本研究旨在使用生物和酶指示剂评估iHP的扩散效果及其去污能力。
方法
使用一个容积为880立方英尺的气密熏蒸室进行去污试验。在去污过程中，将空的动物笼子放置在室内以限制熏蒸剂的分布。在整个去污室内的11个位置放置了孢子和酶指示剂。使用TOMI的SteraMist环境系统和SteraMist溶液产生iHP，过氧化氢浓度为7.8%，剂量为每立方英尺0.5毫升。
结果
在1小时、2小时、6小时和12小时的去污过程中，置于特卫强信封中的不锈钢（SS）圆盘上的生物指示剂的灭活率分别为94%、97%、100%和100%。对于置于SS圆盘和特卫强信封中的[具体指标未明确]，其灭活率分别为82%、68%、100%和100%，而对于置于SS条带上的[具体指标未明确]，其有效率分别为88%、67%、91%和100%。
结论
iHP可使孢子失活，并且随着接触时间的延长，由于灭活的均匀性，在不使用振荡风扇的情况下，残余的tAK活性表明存在类似气体的熏蒸剂扩散。
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