Moosavian Seyedeh Parisa, Maharat Maryam, Chambari Mahla, Moradi Fateme, Rahimlou Mehran
Department of Community Nutrition Improvement, Vice-Chancellery for Health, Shiraz University of Medical Sciences, Shiraz, Iran.
Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran.
Complement Ther Med. 2022 Dec;71:102883. doi: 10.1016/j.ctim.2022.102883. Epub 2022 Aug 28.
Tart cherries are rich in bioactive compounds, such as anthocyanins and other phytochemicals known to have antioxidant properties and exert cardiovascular protective effects. However, there is no definitive consensus on this context. The present systematic review and meta-analysis aimed to investigate the effect of tart cherry juice consumption on cardio-metabolic risk factors.
A systematic search was conducted on electronic databases, including PubMed, Web of Science, Scopus, and Google Scholar from inception up to December 2021 to identify eligible RCT studies. A random-effect model was utilized to estimate the weighted mean difference (WMD) and 95% confidence (95% CI).
Ten RCTs were included in the present meta-analysis. The pooled analysis revealed that tart cherry juice consumption led to a significant reduction in the fasting blood sugar (FBS) levels (WMD = -0.51 mg/dl [95% CI: -0.98, -0.06]). This lowering effect of FBS was robust in subgroups with cross-over studies, participants with age range ≥ 40, duration of follow-up ≤ 4 weeks, and baseline BMI ≥ 30. In contrast, tart cherry juice had no effect on total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), insulin, body mass index (BMI), fat mass, systolic and diastolic blood pressure. However, in the subgroup analysis, some significant effects were observed for insulin, TG, TC, LDL-C, and HDL-C.
In summary, this meta-analysis showed that tart cherry juice mostly had a favorable effect on FBG levels. However, further RCTs with long-term intervention with different doses of administration are needed.
酸樱桃富含生物活性化合物，如花色苷和其他已知具有抗氧化特性并发挥心血管保护作用的植物化学物质。然而，在这方面尚无明确共识。本系统评价和荟萃分析旨在研究饮用酸樱桃汁对心脏代谢危险因素的影响。
对电子数据库进行系统检索，包括从数据库建立至2021年12月的PubMed、科学网、Scopus和谷歌学术，以确定符合条件的随机对照试验研究。采用随机效应模型估计加权平均差（WMD）和95%置信区间（95%CI）。
本荟萃分析纳入了10项随机对照试验。汇总分析显示，饮用酸樱桃汁可使空腹血糖（FBS）水平显著降低（WMD=-0.51mg/dl[95%CI：-0.98，-0.06]）。在交叉研究亚组、年龄范围≥40岁的参与者、随访时间≤4周的参与者以及基线体重指数≥30的亚组中，FBS的这种降低作用较为显著。相比之下，酸樱桃汁对总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、胰岛素、体重指数（BMI）、脂肪量、收缩压和舒张压均无影响。然而，在亚组分析中，观察到胰岛素、TG、TC、LDL-C和HDL-C有一些显著影响。
总之，本荟萃分析表明，酸樱桃汁大多对空腹血糖水平有有益影响。然而，需要进一步开展不同剂量长期干预的随机对照试验。
