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芬兰中年男性饮酒与冠状动脉性猝死

Alcohol consumption and sudden coronary death in middle-aged Finnish men.

作者信息

Suhonen O, Aromaa A, Reunanen A, Knekt P

出版信息

Acta Med Scand. 1987;221(4):335-41. doi: 10.1111/j.0954-6820.1987.tb03353.x.

Abstract

The association between consumption of alcoholic beverages (spirits, beer and wine) and coronary heart disease (CHD) mortality, especially the incidence of sudden coronary death (SCD), was investigated in a 5-year prospective population study comprising 4,532 men aged 40-64 years. The amount of alcohol used was estimated on the basis of answers to a self-filled structured questionnaire. The incidence of SCD was statistically significantly lower among abstainers than among alcohol consumers. The relative risk of SCD of alcohol consumers in comparison with abstainers was largest in the oldest age group and it became more apparent after a follow-up of a couple of years. Only the consumption of spirits was positively associated with the incidence of SCD. Among non-smokers the incidence of SCD was statistically significantly higher in consumers than in abstainers, a similar but not significant trend was observed among current smokers. The positive association between alcohol consumption and incidence of SCD was detected both in CHD-free men and in men with prior CHD. Consumption of alcoholic beverages, and in particular of spirits, is associated with an increased risk of SCD in Finnish men.

摘要

在一项为期5年的前瞻性人群研究中,对4532名年龄在40 - 64岁的男性进行了调查,以研究酒精饮料(烈性酒、啤酒和葡萄酒)的消费与冠心病(CHD)死亡率,特别是心源性猝死(SCD)发生率之间的关联。酒精摄入量是根据自行填写的结构化问卷的回答来估算的。在不饮酒者中,SCD的发生率在统计学上显著低于饮酒者。与不饮酒者相比,饮酒者发生SCD的相对风险在年龄最大的组中最高,并且在随访几年后变得更加明显。只有烈性酒的消费与SCD的发生率呈正相关。在不吸烟者中,饮酒者的SCD发生率在统计学上显著高于不饮酒者,在当前吸烟者中也观察到了类似但不显著的趋势。在无冠心病的男性和既往有冠心病的男性中,均检测到酒精消费与SCD发生率之间存在正相关。在芬兰男性中,酒精饮料的消费,尤其是烈性酒的消费,与SCD风险增加有关。

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