Pan-Cancer Analysis of the Oncogenic and Immunological Role of Solute Carrier Family 6 Member 8 (SLC6A8).

There is mounting evidence on the implication of in the initiation and progression of human cancers. However, a comprehensive understanding of the role of in pan-cancer remains elusive yet. Bioinformatics analysis was performed to investigate the expression and mutation profiles of in cancers, and the association of expression with cancer patients' survival and immune cell infiltration. In general, is significantly upregulated across multiple cancers. expression was inconsistently prognostic in different types of cancer, albeit associated with favorable survival in the vast majority of cancers. The receiver operating characteristic curves showed that was relatively accurate in identifying possible cancer patients. The genetic alteration of , including mutation, amplification and deletion, was frequently present across various types of cancer. Mechanistically, might be involved in tumorigenesis through "carbon metabolism" and "HIF-1 signaling pathway." Besides, expression had significant correlation with immune checkpoints genes and tumor-infiltrating immune cell abundances. The present study offers a novel insight into the roles of in the oncogenesis and development of multiple common cancers.