Yang Gang, Huang Tianyu, Wu Ye, Wang Jinian, Pan Zhipeng, Chen Yuting, Pan Faming, Wang Yuanyin
Oral and Maxillofacial Surgery, Stomatologic Hospital & College, Anhui Medical University, Hefei, China.
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China.
Transl Cancer Res. 2022 Aug;11(8):2536-2552. doi: 10.21037/tcr-22-652.
Long non-coding RNAs (lncRNAs) have been demonstrated to possess critical biological functions that regulate occurrence and progression of tumors. The HOX transcript antisense intergenic RNA (HOTAIR) is one of the most studied lncRNAs. This study was designed to investigate the association of HOTAIR expressions with clinicopathologic features and prognosis in head and neck squamous cell carcinoma (HNSCC).
The PubMed, Web of Science, Embase, Cochrane Library and SCOPUS databases were searched. The studies published before September 10, 2021 were screened. Two authors independently screened the literature and extracted data based on inclusion and exclusion criteria. Meta-analysis, bias assessment, sensitivity analysis and subgroup analysis were performed to improve accuracy and reliability.
Seven studies comprising 546 patients were analysed to clarify the relationship between clinicopathologic features and HOTAIR expression, and six studies with 856 patients were applied to evaluate the effects of HOTAIR expressions on the prognosis. After removing those outliers through Galbraith plots and/or sensitivity analysis, the pooled results showed high HOTAIR expressions were associated with high T stage [odds ratio (OR) =2.32, 95% confidence interval (CI): 1.38-3.89, P=0.001], lymphnode metastasis (OR =2.71, 95% CI: 1.57-4.67, P=0.0003), high TNM stage (OR =3.92, 95% CI: 2.28-6.72, P<0.00001), poor histological grade (OR =2.21, 95% CI: 1.02-4.83, P=0.046), poor overall survival (OS) [hazard ratio (HR) =1.74, 95% CI: 1.19-2.56, P=0.005] and poor disease-free survival (DFS) (HR =1.64, 95% CI: 1.09-2.47, P=0.02). Subgroup analyses of T stage, lymphnode metastasis and histological grade identified possible heterogeneity sources, respectively ethnicity, cut-off, and detection methods.
These findings suggest HOTAIR might serve as an excellent prognostic biomarker and predictor of clinicopathologic features in HNSCC.
长链非编码RNA（lncRNA）已被证明具有调节肿瘤发生和进展的关键生物学功能。HOX转录本反义基因间RNA（HOTAIR）是研究最多的lncRNA之一。本研究旨在探讨HOTAIR表达与头颈部鳞状细胞癌（HNSCC）临床病理特征及预后的关系。
检索PubMed、Web of Science、Embase、Cochrane图书馆和SCOPUS数据库。筛选2021年9月10日前发表的研究。两位作者根据纳入和排除标准独立筛选文献并提取数据。进行荟萃分析、偏倚评估、敏感性分析和亚组分析以提高准确性和可靠性。
分析了7项研究共546例患者以阐明临床病理特征与HOTAIR表达之间的关系，6项研究共856例患者用于评估HOTAIR表达对预后的影响。通过Galbraith图和/或敏感性分析去除异常值后，汇总结果显示HOTAIR高表达与高T分期[比值比（OR）=2.32，95%置信区间（CI）：1.38 - 3.89，P = 0.001]、淋巴结转移（OR = 2.71，95% CI：1.57 - 4.67，P = 0.0003）、高TNM分期（OR = 3.92，95% CI：2.28 - 6.72，P < 0.00001）、组织学分级差（OR = 2.21，95% CI：1.02 - 4.83，P = 0.046）、总生存期（OS）差[风险比（HR） = 1.74，95% CI：1.19 - 2.56，P = 0.005]和无病生存期（DFS）差（HR = 1.64，95% CI：1.09 - 2.47，P = 0.02）相关。T分期、淋巴结转移和组织学分级的亚组分析分别确定了可能的异质性来源，即种族、截断值和检测方法。
这些发现表明HOTAIR可能是HNSCC中一个优秀的预后生物标志物和临床病理特征的预测指标。
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