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精准过敏分子诊断(PAMD@)在监测原发性食物过敏儿童特应性进程中的应用:病例报告

The Precision Allergy Molecular Diagnosis (PAMD@) in Monitoring the Atopic March in a Child with a Primary Food Allergy: Case Report.

作者信息

Knyziak-Mędrzycka Izabela, Szychta Monika, Majsiak Emilia, Fal Andrzej M, Doniec Zbigniew, Cukrowska Bożena

机构信息

Allergy Clinic, Children's Memorial Health Institute, Warsaw, Poland.

The Department of Allergy, Pulmonary Diseases and Internal Medicine, Central Clinical Hospital of the Ministry of Interior and Administration in Warsaw, Warsaw, Poland.

出版信息

J Asthma Allergy. 2022 Sep 7;15:1263-1267. doi: 10.2147/JAA.S372928. eCollection 2022.

Abstract

The case of a 9-month-old boy with an initial diagnosis of atopic dermatitis and confirmed allergy to hen's egg, cow's milk allergens with episodes of anaphylaxis who developed birch allergy whilst under observation with asthma symptoms was presented. The precision allergy molecular diagnosis (PAMD @) allowed for individualisation of dietary recommendations and observing the early progression of food sensitisation to the main birch molecule. The presented identification of major allergic molecules with PAMD@ in the preclinical phase of asthma contributes to the discussion related to early specific immunotherapy to suppress molecular spread and allergic march. However, more research is needed to verify this hypothesis.

摘要

报告了一名9个月大男童的病例,其最初诊断为特应性皮炎,对鸡蛋、牛奶过敏原过敏并伴有过敏反应发作,在观察期间出现哮喘症状时又患上了桦树过敏。精准过敏分子诊断(PAMD@)有助于个性化饮食建议,并观察食物致敏向主要桦树分子的早期进展。在哮喘临床前期阶段通过PAMD@对主要过敏分子进行的鉴定,有助于有关早期特异性免疫疗法以抑制分子扩散和过敏进程的讨论。然而,需要更多研究来验证这一假设。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5fe/9464625/b25602f7ceb3/JAA-15-1263-g0001.jpg

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