World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.
Laboratory of Data Discovery for Health, Hong Kong Science and Technology Park, New Territories, Hong Kong Special Administrative Region, China.
J Infect Dis. 2023 Jan 11;227(2):251-255. doi: 10.1093/infdis/jiac380.
We administered BNT162b2 as a third dose to 314 adults aged ≥30 years who had previously received 2 doses of inactivated vaccine. We collected blood samples before the third dose and again after 1 month and 6 months, and found robust antibody responses to the ancestral strain at 6 months after receipt of BNT162b2. Antibody responses to Omicron BA.2 by live virus neutralization were weaker after the third dose and had declined to a low level by 6 months.
我们给 314 名年龄≥30 岁的既往接种过 2 剂灭活疫苗的成年人接种了 BNT162b2 作为第三剂。我们在第三剂之前和之后 1 个月和 6 个月采集了血样,并发现 BNT162b2 接种后 6 个月时对原始株有强烈的抗体反应。对活病毒中和后 BA.2 奥密克戎的抗体反应在第三剂后减弱,到 6 个月时已降至低水平。