Ahmet'yanov M A, Reikhert L I, Kicherova O A, Veeva D M, Makarova D V
Tyumen State Medical University, Russian Ministry of Health, Tyumen, Russia.
Neurosci Behav Physiol. 2022;52(5):645-648. doi: 10.1007/s11055-022-01290-8. Epub 2022 Sep 13.
Healthy sleep is required to ensure the body's homeostatic stability, the consistency of immunological reactions, and optimum functioning of the internal organs, the nervous system, and cognitive functions. Patterns of changes to the circadian rhythms have been studied in many diseases, though infection with SARS-CoV-2 is a new reality and the basic mechanisms of functioning of the body in this pathology require deeper investigation. Despite the difficulty of analytical investigations in pandemic conditions, experience of the diagnosis of COVID-19 has now been acquired and treatment algorithms have been developed for different clinical situations; vaccines have been developed. Least studied are questions of the long-term sequelae of COVID-19. At the same time, there are good grounds for suggesting that patients need long-term rehabilitation in the post-covid period of SARS-CoV-2, for reasons including damage to the nervous system. Analysis of publications - from descriptions of clinical cases to literature reviews - allows empirical experience to be accumulated, providing the opportunity for future identification of prognostic markers for the disease for effective prevention of long-term sequelae. The results of current prospective studies draw attention to the occurrence of dyssomnia and obstructive sleep apnea not only as a common consequence of coronavirus infection, but also as a factor significantly worsening the prognosis in the acute period of illness. It has repeatedly been shown that sleep deprivation has adverse influences on the body's resistance, including to SARS-CoV-2, and requires correction to improve prognoses in the acute and long-term periods of illness in COVID-19 patients.
健康睡眠对于确保身体的稳态稳定性、免疫反应的一致性以及内脏器官、神经系统和认知功能的最佳运作至关重要。昼夜节律的变化模式已在许多疾病中得到研究,尽管感染严重急性呼吸综合征冠状病毒2(SARS-CoV-2)是一个新情况,且在这种病理状态下身体的基本运作机制需要更深入的研究。尽管在大流行情况下进行分析调查存在困难,但目前已获得了新型冠状病毒肺炎(COVID-19)的诊断经验,并针对不同临床情况制定了治疗方案;还研发出了疫苗。对COVID-19长期后遗症的研究最少。与此同时,有充分理由表明,由于包括神经系统损伤在内的原因,患者在感染SARS-CoV-2后的康复期需要长期康复治疗。对从临床病例描述到文献综述等出版物的分析有助于积累经验,为未来识别该疾病的预后标志物提供机会,从而有效预防长期后遗症。当前前瞻性研究的结果提醒人们,睡眠障碍和阻塞性睡眠呼吸暂停不仅是冠状病毒感染的常见后果,也是疾病急性期预后显著恶化的一个因素。反复研究表明,睡眠剥夺会对身体抵抗力产生不利影响,包括对SARS-CoV-2的抵抗力,因此需要加以纠正,以改善COVID-19患者急性期和长期疾病的预后。