Fu Dongliao, Hu Zhigang, Xu Xinyang, Dai Xiaoyan, Liu Ziyi
College of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang 471023, China.
Zhengzhou Foreign Language School, Zhengzhou, Henan 450001, China.
Transl Oncol. 2022 Dec;26:101510. doi: 10.1016/j.tranon.2022.101510. Epub 2022 Sep 16.
Several different signaling pathways and molecular mechanisms have been identified as responsible for controlling critical functions in human cancer cells, such as selective growth and proliferative advantage, altered stress response favoring overall survival, vascularization, invasion and metastasis, metabolic rewiring, an abetting microenvironment, and immune modulation. This concise summary will provide a selective review of recent studies of key signal transduction pathways, including mitogen-activated protein kinase (MAPK) pathway, Phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling, and Wnt/β-catenin signaling pathway, which are altered in cancer cells, as the novel and promising therapeutic targets.
已经确定了几种不同的信号通路和分子机制，它们负责控制人类癌细胞中的关键功能，如选择性生长和增殖优势、有利于整体生存的应激反应改变、血管生成、侵袭和转移、代谢重编程、促进微环境以及免疫调节。本简要综述将对关键信号转导通路的近期研究进行选择性回顾，包括有丝分裂原激活蛋白激酶（MAPK）通路、磷脂酰肌醇-3-激酶（PI3K）/AKT/雷帕霉素哺乳动物靶蛋白（mTOR）信号通路以及Wnt/β-连环蛋白信号通路，这些通路在癌细胞中发生改变，是新型且有前景的治疗靶点。
Zotero 插件
