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异基因造血干细胞移植后边缘叶脑炎

Limbic Encephalitis following Allogeneic Hematopoietic Stem Cell Transplantation.

作者信息

Johansen Silje, Kråkenes Jostein, Vedeler C A, Storstein Anette Margrethe, Reikvam Håkon

机构信息

Department of Medicine, Haraldsplass Deaconess Hospital, N-5021 Bergen, Bergen, Norway.

Department of Radiology, Haukeland University Hospital, N-5021 Bergen, Norway.

出版信息

Case Reports Immunol. 2022 Sep 10;2022:4174755. doi: 10.1155/2022/4174755. eCollection 2022.

Abstract

A woman with myelodysplastic syndrome (MDS) was treated with allogeneic hematopoietic stem cell transplantation (allo-HSCT). 65 days after the transplantation, she developed fatigue and central neurological symptoms. Clinical workup including magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) examination revealed findings suspicious for limbic encephalitis (LE), successfully treated with intravenous immunoglobulins and intravenous corticosteroids. Although a rare complication after allo-HSCT, physicians should be aware of neurological symptoms that develop throughout the transplantation course.

摘要

一名患有骨髓增生异常综合征(MDS)的女性接受了异基因造血干细胞移植(allo-HSCT)。移植后65天,她出现疲劳和中枢神经系统症状。包括磁共振成像(MRI)和脑脊液(CSF)检查在内的临床检查发现了疑似边缘叶脑炎(LE)的表现,通过静脉注射免疫球蛋白和静脉注射皮质类固醇成功治疗。尽管这是allo-HSCT后一种罕见的并发症,但医生应注意在整个移植过程中出现的神经系统症状。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07ac/9482550/b58b849c5845/CRII2022-4174755.001.jpg

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