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少即是多?铜绿假单胞菌呼吸机相关性肺炎的抗生素治疗疗程

Less Is More? Antibiotic Treatment Duration in Pseudomonas aeruginosa Ventilator-Associated Pneumonia.

作者信息

Albin Owen R, Kaye Keith S, McCreary Erin K, Pogue Jason M

机构信息

Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.

Department of Internal Medicine, Division of Infectious Diseases, Allergy and Immunology, Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.

出版信息

Clin Infect Dis. 2023 Feb 18;76(4):745-749. doi: 10.1093/cid/ciac784.

Abstract

Recommended antimicrobial treatment durations for ventilator-associated pneumonia (VAP) caused by Pseudomonas aeruginosa have evolved over the past few decades. In this Viewpoint, we provide a narrative review of landmark trials investigating antimicrobial treatment durations for VAP caused by P. aeruginosa, and appraise iterations of expert consensus guidelines based on these data. We highlight strengths and weaknesses of existing data on this topic and provide recommendations for future avenues of study.

摘要

在过去几十年中,针对铜绿假单胞菌引起的呼吸机相关性肺炎(VAP)的推荐抗菌治疗疗程不断演变。在本观点文章中,我们对调查铜绿假单胞菌引起的VAP抗菌治疗疗程的里程碑式试验进行了叙述性综述,并根据这些数据评估了专家共识指南的迭代情况。我们强调了关于该主题现有数据的优缺点,并为未来的研究方向提供了建议。

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