视网膜血管炎的视网膜电图检查结果。
Electroretinographic findings in retinal vasculitis.
机构信息
Byers Eye Institute, Stanford University, Palo Alto, California, USA.
Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
出版信息
Br J Ophthalmol. 2023 Nov 22;107(12):1834-1838. doi: 10.1136/bjo-2022-321716.
AIM
To describe and correlate electroretinographic responses with clinical and angiographic findings in retinal vasculitis (RV).
METHODS
Medical records of patients with diagnosis of RV at a tertiary eye centre from December 2017 to May 2021 were reviewed. Cases in which fluorescein angiography (FFA) and full field electroretinography (ffERG) were done within 1 month were included. FFAs were graded according to the Angiography Scoring for Uveitis Working Group from 0 to 40, where 0 is normal. A novel ffERG grading system was implemented where individual waves were graded for timing and amplitude and general ffERG score was determined with 6 being a perfect score.
RESULTS
20 patients (34 eyes) were included. Mean age was 43.9±19.8 years; 70% were female. Median best-corrected visual acuity was 0.8 (0.08-1). Mean FFA score was 12.6±6.5. Median general ffERG score was 5 (0-6). 68% and 91% of eyes had responses with general ffERG scores ≥5 and 4, respectively. Flicker timing was most commonly affected.FFA scores weakly correlated with delayed photopic cone b-wave and flicker timing (p=0.03 and 0.016, respectively). Vitreous haze moderately correlated with delayed cone b-wave timing (p<0.001), delayed flicker timing (p=0.002) and weakly correlated with lower flicker amplitude (p=0.03). Underlying systemic disease was associated with poor ffERG responses.
CONCLUSION
In this study, RV was not frequently associated with severe global retinal dysfunction Higher FFA scores, and vitreous haze grading were weakly, but significantly, correlated with cone-generated ffERG responses.
目的
描述并将视网膜血管炎（RV）的视网膜电图反应与临床和血管造影结果相关联。
方法
回顾了 2017 年 12 月至 2021 年 5 月在一家三级眼科中心诊断为 RV 的患者的病历。包括在 1 个月内完成荧光素血管造影（FFA）和全视野视网膜电图（ffERG）的病例。FFA 根据葡萄膜炎血管造影工作组的评分从 0 到 40 进行分级，其中 0 表示正常。实施了一种新的 ffERG 分级系统，其中对个体波进行定时和幅度分级，并使用 6 确定总体 ffERG 评分作为完美评分。
结果
共纳入 20 例（34 只眼）患者。平均年龄为 43.9±19.8 岁；70%为女性。最佳矫正视力的中位数为 0.8（0.08-1）。平均 FFA 评分为 12.6±6.5。一般 ffERG 评分的中位数为 5（0-6）。分别有 68%和 91%的眼的 ffERG 评分≥5 和 4。闪光定时最常受影响。FFA 评分与光适应锥细胞 b 波和闪光定时延迟呈弱相关（p=0.03 和 0.016）。玻璃体内混浊与锥细胞 b 波时相延迟（p<0.001）、闪光时相延迟（p=0.002）中度相关，与闪光振幅降低（p=0.03）弱相关。基础系统性疾病与较差的 ffERG 反应相关。
结论
在这项研究中，RV 并不常伴有严重的视网膜整体功能障碍。较高的 FFA 评分和玻璃体内混浊分级与锥细胞产生的 ffERG 反应呈弱相关，但具有统计学意义。
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