一种用于病毒交联的三重重氮试剂和一种偶氮键合的分子笼的合成。
A triple-diazonium reagent for virus crosslinking and the synthesis of an azo-linked molecular cage.
机构信息
State Key Laboratory of Organic-Inorganic Composites and Beijing Key Lab of Bioprocess, Beijing University of Chemical Technology, Beijing 100029, China.
State Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology, College of Chemistry, National Pesticide Engineering Research Center, Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, Tianjin 300071, China.
出版信息
Org Biomol Chem. 2022 Oct 5;20(38):7577-7581. doi: 10.1039/d2ob01583h.
The first bench-stable triple-diazonium reagent (TDA-1) was rationally designed and synthesized for coupling and crosslinking. The three reactive sites of TDA-1 can react with phenol-containing molecules as well as plant viruses in aqueous buffers efficiently. In addition, a new-type azo-linked cage was constructed by the direct reaction of TDA-1 with a triple-phenol molecule and was characterized by X-ray crystallography.
首个稳定的三联重氮试剂（TDA-1）被合理设计并合成用于偶联和交联。TDA-1 的三个反应位点可以在水缓冲液中有效地与含酚分子以及植物病毒反应。此外，通过 TDA-1 与三酚分子的直接反应构建了一种新型的偶氮连接笼，并通过 X 射线晶体学进行了表征。
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