Curie Catia Angli, Darmawan Muhammad Arif, Dianursanti Dianursanti, Budhijanto Wiratni, Gozan Misri
Chemical Engineering Department, Faculty of Engineering, Universitas Indonesia, Depok 16424, Indonesia.
Department of Chemical Engineering, Universitas Pertamina, Jakarta 12220, Indonesia.
Polymers (Basel). 2022 Sep 15;14(18):3856. doi: 10.3390/polym14183856.
Contradictions have been reported on the effect of organic solvents, especially toluene, on enzymatic ring-opening polymerization (eROP) of L-lactide. Studies have shown that log P, a common measure of hydrophilicity, affects enzyme activity. This study examines the effect of solvents with various log P values on the eROP of L-lactide, performed using lipase (CRL). N,N-dimethylacetamide (DMA), 1,2-dimethoxybenzene, 1,4-dimethoxybenzene, diphenyl ether, and dodecane were used as the organic solvents. The eROP in ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate ([BMIM][PF]) was also conducted to compare its performance with the organic solvents. The results show that [BMIM][PF]-mediated eROP gave better conversion and molecular weight than the organic solvent-mediated eROP. In this study, the effects of solvents hydrophilicity are discussed, including the possibility of hexafluorophosphate ion ([PF]) hydrolysis to occur.
关于有机溶剂，尤其是甲苯，对L-丙交酯酶促开环聚合反应（eROP）的影响，已有相互矛盾的报道。研究表明，log P（一种衡量亲水性的常用指标）会影响酶的活性。本研究考察了具有不同log P值的溶剂对使用脂肪酶（CRL）进行的L-丙交酯eROP的影响。N，N-二甲基乙酰胺（DMA）、1,2-二甲氧基苯、1,4-二甲氧基苯、二苯醚和十二烷被用作有机溶剂。还在离子液体1-丁基-3-甲基咪唑六氟磷酸盐（[BMIM][PF]）中进行了eROP，以将其性能与有机溶剂进行比较。结果表明，[BMIM][PF]介导的eROP比有机溶剂介导的eROP具有更高的转化率和分子量。在本研究中，讨论了溶剂亲水性的影响，包括六氟磷酸根离子（[PF]）发生水解的可能性。
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