Liu Jun, Rui Ke, Peng Na, Luo Hui, Zhu Bo, Zuo Xiaoxia, Lu Liwei, Chen Jixiang, Tian Jie
Institute of Medical Immunology, Affiliated Hospital of Jiangsu University, Zhenjiang, China; Department of Laboratory Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Institute of Medical Immunology, Affiliated Hospital of Jiangsu University, Zhenjiang, China; Department of Laboratory Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Cytokine Growth Factor Rev. 2022 Dec;68:69-80. doi: 10.1016/j.cytogfr.2022.09.003. Epub 2022 Sep 14.
Recent studies have illustrated the functional significance of DNA recognition in the activation of innate immune responses among a variety of diseases. The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway has been found to be modulated by post-translational modifications and can regulate the immune response via type I IFNs. Accumulating evidence indicates a pivotal role of cGAS-STING signaling, being protective or pathogenic, in the development of diseases. Thus, a comprehensive understanding of the post-translational modifications of cGAS-STING pathway and their role in disease development will provide insights in predicting individual disease outcomes and developing appropriate therapies. In this review, we will discuss the regulation of the cGAS-STING pathway and its implications in disease pathologies, as well as pharmacologic strategies to target the cGAS-STING pathway for therapeutic intervention.
近期研究已阐明了DNA识别在多种疾病的先天性免疫反应激活中的功能意义。环磷酸鸟苷-腺苷酸合成酶-干扰素基因刺激因子（cGAS-STING）通路已被发现受翻译后修饰调控，并可通过I型干扰素调节免疫反应。越来越多的证据表明，cGAS-STING信号在疾病发展过程中起着关键作用，既具有保护作用，也具有致病作用。因此，全面了解cGAS-STING通路的翻译后修饰及其在疾病发展中的作用，将为预测个体疾病结局和制定适当的治疗方案提供思路。在这篇综述中，我们将讨论cGAS-STING通路的调控及其在疾病病理学中的意义，以及针对cGAS-STING通路进行治疗干预的药理学策略。
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