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血小板-淋巴细胞比值、中性粒细胞-淋巴细胞比值及其与 2 型糖尿病的动态变化：中国的一项队列研究。

Platelet-Lymphocyte Ratio, Neutrophil-Lymphocyte Ratio and Their Dynamic Changes with Type 2 Diabetes Mellitus: A Cohort Study in China.

机构信息

Department of Epidemiology and Health Statistics, Shenzhen University Health Science Center, Shenzhen, GD, China.

2019 Preventive Medicine, School of Public Health, Shenzhen University Health Science Center, Shenzhen, GD, China.

出版信息

Endocr Res. 2022 Aug-Nov;47(3-4):138-152. doi: 10.1080/07435800.2022.2127757. Epub 2022 Sep 26.

DOI:10.1080/07435800.2022.2127757

PMID:36163006

Abstract

BACKGROUND

This study aimed at investigating the relationships between Platelet-Lymphocyte ratio (PLR) and Neutrophil-Lymphocyte ratio (NLR) and their dynamic changes (∆PLR, ∆NLR) with type 2 diabetes mellitus (T2DM) in a Chinese cohort study.

METHODS

This study recruited 41,439 individuals who were diagnosed without T2DM at first health examination and completed at least one follow-up. The relationships between NLR, PLR, ∆PLR, ∆NLR and T2DM risk were analyzed using the Cox regression model with corresponding Hazard Ratios (HRs) and 95% Confidence Intervals (CIs).

RESULTS

PLR exhibited significant correlation with T2DM risk in a linear reverse dose-response pattern, the corresponding HRs and 95% CIs were 0.81 (0.72, 0.90), 0.71 (0.63, 0.80) and 0.56 (0.49, 0.64) respectively ( < 0.001) for Q2, Q3 and Q4 vs Q1 after adjusting for age, gender, BMI, TG, TC, HDL-C, FPG, ALT, AST, heart rate, smoking, family history of diabetes, and alcohol consumption at baseline in Model 3. The significance remained in subgroups of women, <45 years, ≥45 years, BMI ≥ 24, with fatty liver disease, without fatty liver disease and normotension. Comparing with the largest decrease group of NLR (∆NLR < -0.32), the risk of T2DM increased for -0.003 ≤ ∆NLR < 0.31 (HR 1.17, 95% CI 1.01-1.36) and ∆NLR ≥ 0.31 (HR 1.23, 95% CI 1.06-1.43).

CONCLUSIONS

Higher PLR could reduce the risk of T2DM. Larger increase of NLR could increase T2DM risk.

摘要

背景

本研究旨在调查血小板与淋巴细胞比值（PLR）和中性粒细胞与淋巴细胞比值（NLR）及其动态变化（∆PLR、∆NLR）与中国人群 2 型糖尿病（T2DM）之间的关系。

方法

本研究共纳入 41439 名个体，他们在首次体检时未被诊断为 T2DM，且至少完成了一次随访。使用 Cox 回归模型分析 NLR、PLR、∆PLR、∆NLR 与 T2DM 风险的关系，并计算相应的风险比（HR）及其 95%置信区间（CI）。

结果

PLR 与 T2DM 风险呈线性反向剂量-反应关系，调整年龄、性别、BMI、TG、TC、HDL-C、FPG、ALT、AST、心率、吸烟、糖尿病家族史和饮酒等因素后，Q2、Q3 和 Q4 与 Q1 相比，HR 及其 95%CI 分别为 0.81（0.72，0.90）、0.71（0.63，0.80）和 0.56（0.49，0.64）（均<0.001）。在女性、<45 岁、≥45 岁、BMI≥24、有脂肪肝、无脂肪肝和血压正常的亚组中，该结果仍具有统计学意义。与 NLR 最大降幅组（∆NLR <-0.32）相比，-0.003≤∆NLR<0.31（HR 1.17，95%CI 1.01-1.36）和 ∆NLR≥0.31（HR 1.23，95%CI 1.06-1.43）的 T2DM 发病风险增加。