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精液菌群失调——仅仅是男性的问题吗?

Semen dysbiosis-just a male problem?

机构信息

Department of Microbiology, Faculty of Medicine, University of Technology in Katowice, Katowice, Poland.

Gyncentrum Sp. z o.o. Laboratory of Molecular Biology and Virology, Katowice, Poland.

出版信息

Front Cell Infect Microbiol. 2022 Sep 13;12:815786. doi: 10.3389/fcimb.2022.815786. eCollection 2022.

Abstract

Seminal microflora is crucial to male fertility. Dysbiosis-disturbance of quantitative ratios of individual bacteria or appearance of pathogenic species-rarely results in symptomatic disease. Inflammation results in decreased sperm production, lower motility, or morphological changes and, in the long term, can cause ejaculatory duct obstruction, leading to infertility. Moreover, it may cause infection of the partner's female genital tract. Dysbiosis in both partners results in fertility problems, disorders in embryo implantation, or miscarriages. In addition, chronic inflammation of the male genitourinary system may accelerate the appearance of antisperm antibodies. A comprehensive examination of seminal microflora can clarify the causes of infertility or prevent pathological conditions that affect seminal parameters. Seminal microflora as a direct impact on fertility problems as well as a decrease in the effectiveness of assisted reproduction methods, insemination, or procedures.

摘要

精液微生物群对男性生育力至关重要。微生态失调(即个别细菌数量比例失调或出现病原性物种)很少导致有症状的疾病。炎症会导致精子生成减少、活力降低或形态改变,长期下去会导致射精管阻塞,导致不育。此外,它还可能导致伴侣的女性生殖道感染。夫妻双方的微生态失调会导致生育问题、胚胎着床障碍或流产。此外,男性泌尿生殖系统的慢性炎症可能会加速抗精子抗体的出现。对精液微生物群进行全面检查可以明确不孕的原因,或预防影响精液参数的病理状况。精液微生物群会直接影响生育问题,以及降低辅助生殖方法(如授精或程序)的效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5b5/9514095/468568662140/fcimb-12-815786-g001.jpg

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