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胃肠急诊手术:发病率和死亡率评估。意大利一项前瞻性多中心研究方案,用于评估不同年龄组腹部急诊手术的负担。(GESEMM研究)

Gastro-intestinal emergency surgery: Evaluation of morbidity and mortality. Protocol of a prospective, multicenter study in Italy for evaluating the burden of abdominal emergency surgery in different age groups. (The GESEMM study).

作者信息

Costa Gianluca, Fransvea Pietro, Puccioni Caterina, Giovinazzo Francesco, Carannante Filippo, Bianco Gianfranco, Catamero Alberto, Masciana Gianluca, Miacci Valentina, Caricato Marco, Capolupo Gabriella Teresa, Sganga Gabriele

机构信息

Surgery Centre, Colorectal Surgery Unit, Fondazione Policlinico Universitariio Campus Bio-Medico, Università Campus Bio-Medico, Rome, Italy.

Emergency Surgery and Trauma, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Catholic University of Sacred Heart, Rome, Italy.

出版信息

Front Surg. 2022 Sep 16;9:927044. doi: 10.3389/fsurg.2022.927044. eCollection 2022.

Abstract

Gastrointestinal emergencies (GE) are frequently encountered in emergency department (ED), and patients can present with wide-ranging symptoms. more than 3 million patients admitted to US hospitals each year for EGS diagnoses, more than the sum of all new cancer diagnoses. In addition to the complexity of the urgent surgical patient (often suffering from multiple co-morbidities), there is the unpredictability and the severity of the event. In the light of this, these patients need a rapid decision-making process that allows a correct diagnosis and an adequate and timely treatment. The primary endpoint of this Italian nationwide study is to analyze the clinicopathological findings, management strategies and short-term outcomes of gastrointestinal emergency procedures performed in patients over 18. Secondary endpoints will be to evaluate to analyze the prognostic role of existing risk-scores to define the most suitable scoring system for gastro-intestinal surgical emergency. The primary outcomes are 30-day overall postoperative morbidity and mortality rates. Secondary outcomes are 30-day postoperative morbidity and mortality rates, stratified for each procedure or cause of intervention, length of hospital stay, admission and length of stay in ICU, and place of discharge (home or rehabilitation or care facility). In conclusion, to improve the level of care that should be reserved for these patients, we aim to analyze the clinicopathological findings, management strategies and short-term outcomes of gastrointestinal emergency procedures performed in patients over 18, to analyze the prognostic role of existing risk-scores and to define new tools suitable for EGS. This process could ameliorate outcomes and avoid futile treatments. These results may potentially influence the survival of many high-risk EGS procedure.

摘要

胃肠道急症(GE)在急诊科(ED)很常见,患者的症状多种多样。每年有超过300万患者因胃肠道急症诊断而入住美国医院,这一数字超过了所有新发癌症诊断病例数之和。除了急诊手术患者情况复杂(常伴有多种合并症)外,病情还具有不可预测性和严重性。鉴于此,这些患者需要一个快速的决策过程,以实现正确诊断并进行充分及时的治疗。这项意大利全国性研究的主要终点是分析18岁以上患者进行胃肠道急诊手术的临床病理结果、管理策略和短期预后。次要终点将是评估现有风险评分的预后作用,以确定最适合胃肠道外科急诊的评分系统。主要结局是术后30天的总体发病率和死亡率。次要结局是术后30天的发病率和死亡率,按每种手术或干预原因分层,住院时间、入住重症监护病房的时间和出院地点(回家或康复或护理机构)。总之,为了提高对这些患者应提供的护理水平,我们旨在分析18岁以上患者进行胃肠道急诊手术的临床病理结果、管理策略和短期预后,分析现有风险评分的预后作用,并确定适用于胃肠道急症的新工具。这一过程可以改善预后并避免无效治疗。这些结果可能会潜在影响许多高风险胃肠道急症手术患者的生存情况。

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