Department of Urology, Shengjing Hospital of China Medical University, #36 Sanhao Street, Heping District, Shenyang, 110004, Liaoning, China.
Department of Family Medicine, Shengjing Hospital of China Medical University, #36 Sanhao Street, Heping District, Shenyang, 110004, Liaoning, China.
Cell Mol Biol Lett. 2022 Oct 4;27(1):84. doi: 10.1186/s11658-022-00385-x.
Long noncoding RNAs are involved in epigenetic gene modification, including binding to the chromatin rearrangement complex in pre-transcriptional regulation and to gene promoters in gene expression regulation, as well as acting as microRNA sponges to control messenger RNA levels in post-transcriptional regulation. An increasing number of studies have found that long noncoding RNA plasmacytoma variant translocation 1 (PVT1) plays an important role in cancer development. In this review of a large number of studies on PVT1, we found that PVT1 is closely related to tumor onset, proliferation, invasion, epithelial-mesenchymal transformation, and apoptosis, as well as poor prognosis and radiotherapy and chemotherapy resistance in some cancers. This review comprehensively describes PVT1 expression in various cancers and presents novel approaches to the diagnosis and treatment of cancer.
长链非编码 RNA 参与表观遗传基因修饰，包括在转录前调控中与染色质重排复合物结合，在基因表达调控中与基因启动子结合，以及作为 microRNA 海绵在转录后调控中控制信使 RNA 水平。越来越多的研究发现，浆细胞瘤变异易位 1（PVT1）长链非编码 RNA 在癌症发展中起着重要作用。在对大量关于 PVT1 的研究进行综述后，我们发现 PVT1 与肿瘤的发生、增殖、侵袭、上皮-间充质转化和凋亡密切相关，并且在某些癌症中与不良预后和放疗、化疗耐药有关。本综述全面描述了 PVT1 在各种癌症中的表达，并提出了癌症诊断和治疗的新方法。
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