Department of Dermatology, The First People's Hospital of Jingmen, Jingmen, Hubei Province, P.R. China.
Emergency Department, Jingzhou Central Hospital, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei Province, P.R. China.
Medicine (Baltimore). 2022 Sep 23;101(38):e30812. doi: 10.1097/MD.0000000000030812.
There has been an epidemic of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) delta variant in Jingmen, China, and the clinical and epidemiological characteristics of all patients infected with SARS-CoV-2 delta variant in an epidemic are rarely reported. All the coronavirus disease 2019 (COVID-19) patients diagnosed in Jingmen in August 2021 were enrolled in this study. Epidemiological data and clinical characteristics were analyzed. Of 58 patients (38 male and 20 female), 11 were children. The mean age was 35 years, and the median age was 39 years (range, 1-60 years; interquartile range, 28-51). The infectivity of the SARS-CoV-2 Delta variant may have increased, but pathogenicity could have decreased significantly. The vast majority of patients had either no symptoms or mild symptoms. Even though the variant virus is highly contagious, control measures have proven effective. Symptoms included fever (53%), cough (48%), headache (6%), runny nose (13%), loss of smell and taste (6%), elevated C-reactive protein (26%), increased neutrophil count (13%), decreased eosinophil count (21%), and elevated mononuclear granulocytes (26%). Thirty-eight of the 47 adults showed lymphocyte decline, but none of the children showed a significant decline, and more than half of them showed an increase. Thirty patients had no pneumonia, 27 patients had mild pneumonia, and only one patient with multiple chronic diseases had severe pneumonia. None of the 11 children had been vaccinated, 10 did not have pneumonia, and 1 had a small lung lesion. The number of new patients disappeared in 15 days after the lockdown of the city.
中国荆门市出现了严重急性呼吸综合征冠状病毒 2 型(SARS-CoV-2)Delta 变异株流行,流行期间所有感染 SARS-CoV-2 Delta 变异株患者的临床和流行病学特征鲜有报道。本研究纳入了 2021 年 8 月在荆门市诊断的所有 2019 年冠状病毒病(COVID-19)患者。分析了流行病学数据和临床特征。58 例患者中(男 38 例,女 20 例),有 11 例为儿童。患者平均年龄为 35 岁,中位数年龄为 39 岁(范围 1-60 岁;四分位距 28-51)。SARS-CoV-2 Delta 变异株的传染性可能增加,但致病性可能显著降低。绝大多数患者无症状或症状轻微。尽管变异病毒具有高度传染性,但控制措施已被证明是有效的。症状包括发热(53%)、咳嗽(48%)、头痛(6%)、流涕(13%)、嗅觉味觉丧失(6%)、C 反应蛋白升高(26%)、中性粒细胞计数增加(13%)、嗜酸性粒细胞计数减少(21%)和单核细胞增多(26%)。47 例成人中有 38 例出现淋巴细胞减少,但儿童无一例明显减少,且半数以上患儿淋巴细胞增多。30 例患者无肺炎,27 例患者肺炎较轻,仅有 1 例合并多种慢性疾病的患者肺炎较重。11 例儿童均未接种疫苗,10 例无肺炎,1 例患儿肺部有小病灶。城市封锁后 15 天内新发病例消失。