中国系统性红斑狼疮治疗与研究协作组注册研究（CSTAR）十四：系统性红斑狼疮患者的主观幸福感
Chinese SLE Treatment and Research Group Registry (CSTAR) XIV: the subjective well-being of patients with systemic lupus erythematosus.
作者信息
Shi Yue, Bi Dandan, Wang Yanhong, Li Ruofan, Wu Lijun, Zhao Cheng, Wu Zhenbiao, Duan Xinwang, Xu Jian, Zhan Feng, Yang Min, Liu Shengyun, Li Qin, Zhang Shuo, Liu Lingshan, Zhao Jiuliang, Tian Xinping, Li Xinying, Wang Qian, Zeng Xiaofeng
机构信息
Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science and Technology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China.
出版信息
Front Med (Lausanne). 2022 Sep 20;9:984183. doi: 10.3389/fmed.2022.984183. eCollection 2022.
BACKGROUND
Systemic lupus erythematosus (SLE) can significantly influence patients' quality of life and subjective well-being (SWB), but the relationships between clinical characteristics, SWB, and related psychological factors have been little studied.
OBJECTIVE
To measure SWB in patients with SLE and examine how major clinical determinants, emotional variables, and related positive factors affect SWB.
METHODS
Overall, 1,110 patients with SLE from the Chinese SLE Treatment and Research Group (CSTAR) and 198 age and gender-matched individuals from the general population without self-reported SLE were invited to complete questionnaires of SWB evaluated by the satisfaction with life scale (SWLS), emotional variables assessed by the patient health questionnaire-9 (PHQ-9), and general anxiety disorder-7 (GAD-7) and related positive factors assessed by the self-esteem scale (SES), general self-efficacy scale (GESE), and Connor-Davidson resilience scale (CD-RISC). The multivariate linear regression was used to examine the relationship between clinical manifestations and SWB.
RESULTS
Life satisfaction was significantly lower ( < 0.001) in patients with SLE than in the general population. Active skin involvement (OR = 0.923, 95% CI = 0.868-0.981, < 0.05) was negatively associated with life satisfaction scores, and age at enrollment (OR = 1.160, 95% CI = 1.092-1.230, < 0.001) were positively associated with life satisfaction scores in the multivariate regression model. The cumulative organ damage was significantly associated with depression (OR = 1.085, 95% CI = 1.022-1.153, < 0.01) and the loss of self-esteem (OR = 1.067, 95% CI = 1.004-1.133, < 0.05).
CONCLUSION
SWB provides useful insight into the impact of SLE on psychological health and opportunities to improve quality of life and clinical care.
背景
系统性红斑狼疮（SLE）会显著影响患者的生活质量和主观幸福感（SWB），但临床特征、SWB及相关心理因素之间的关系鲜少被研究。
目的
测量SLE患者的SWB，并探究主要临床决定因素、情绪变量及相关积极因素如何影响SWB。
方法
总体而言，邀请了来自中国SLE治疗与研究组（CSTAR）的1110例SLE患者以及198例年龄和性别匹配、自我报告无SLE的普通人群个体，完成由生活满意度量表（SWLS）评估的SWB问卷、由患者健康问卷-9（PHQ-9）和广泛性焦虑障碍量表-7（GAD-7）评估的情绪变量问卷，以及由自尊量表（SES）、一般自我效能感量表（GESE）和康纳-戴维森心理韧性量表（CD-RISC）评估的相关积极因素问卷。采用多元线性回归分析来探究临床表现与SWB之间的关系。
结果
SLE患者的生活满意度显著低于普通人群（<0.001）。在多元回归模型中，活动性皮肤受累（OR=0.923，95%CI=0.868-0.981，<0.05）与生活满意度得分呈负相关，而入选时年龄（OR=1.160，95%CI=1.092-1.230，<0.00I）与生活满意度得分呈正相关。累积器官损伤与抑郁（OR=1.085，95%CI=1.022-1.153，<0.01）和自尊丧失（OR=1.067，95%CI=1.004-1.133，<0.05）显著相关。
结论
SWB为了解SLE对心理健康的影响以及改善生活质量和临床护理提供了有用的见解。
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