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环状 RNA 在 COVID-19 中的治疗前景。

Therapeutic prospects of ceRNAs in COVID-19.

机构信息

Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China.

Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou Science and Technology Bureau, Luzhou, China.

出版信息

Front Cell Infect Microbiol. 2022 Sep 20;12:998748. doi: 10.3389/fcimb.2022.998748. eCollection 2022.

DOI:10.3389/fcimb.2022.998748
PMID:36204652
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9530275/
Abstract

Since the end of 2019, COVID-19 caused by SARS-CoV-2 has spread worldwide, and the understanding of the new coronavirus is in a preliminary stage. Currently, immunotherapy, cell therapy, antiviral therapy, and Chinese herbal medicine have been applied in the clinical treatment of the new coronavirus; however, more efficient and safe drugs to control the progress of the new coronavirus are needed. Long noncoding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs) may provide new therapeutic targets for novel coronavirus treatments. The first aim of this paper is to review research progress on COVID-19 in the respiratory, immune, digestive, circulatory, urinary, reproductive, and nervous systems. The second aim is to review the body systems and potential therapeutic targets of lncRNAs, miRNAs, and circRNAs in patients with COVID-19. The current research on competing endogenous RNA (ceRNA) (lncRNA-miRNA-mRNA and circRNA-miRNA-mRNA) in SARS-CoV-2 is summarized. Finally, we predict the possible therapeutic targets of four lncRNAs, MALAT1, NEAT1, TUG1, and GAS5, in COVID-19. Importantly, the role of PTEN gene in the ceRNA network predicted by lncRNA MALAT1 and lncRNA TUG1 may help in the discovery and clinical treatment of effective drugs for COVID-19.

摘要

自 2019 年底以来，由 SARS-CoV-2 引起的 COVID-19 在全球范围内传播，人们对新型冠状病毒的认识仍处于初步阶段。目前，免疫疗法、细胞疗法、抗病毒疗法和中草药已应用于新型冠状病毒的临床治疗中；然而，需要更有效和安全的药物来控制新型冠状病毒的进展。长链非编码 RNA（lncRNA）、微小 RNA（miRNA）和环状 RNA（circRNA）可能为新型冠状病毒的治疗提供新的治疗靶点。本文的第一个目的是综述 COVID-19 在呼吸系统、免疫系统、消化系统、循环系统、泌尿系统、生殖系统和神经系统中的研究进展。第二个目的是综述 lncRNA、miRNA 和 circRNA 在 COVID-19 患者中对各系统的作用及其潜在的治疗靶点。总结 SARS-CoV-2 中竞争内源性 RNA（ceRNA）（lncRNA-miRNA-mRNA 和 circRNA-miRNA-mRNA）的研究进展。最后，我们预测了 MALAT1、NEAT1、TUG1 和 GAS5 这 4 个 lncRNA 在 COVID-19 中的可能治疗靶点。重要的是，lncRNA MALAT1 和 lncRNA TUG1 预测的 ceRNA 网络中 PTEN 基因的作用可能有助于发现和临床治疗 COVID-19 的有效药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26d3/9530275/fbfcc709e0b1/fcimb-12-998748-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26d3/9530275/4e5b89b6cc4c/fcimb-12-998748-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26d3/9530275/6383d4be9c65/fcimb-12-998748-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26d3/9530275/fbfcc709e0b1/fcimb-12-998748-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26d3/9530275/4e5b89b6cc4c/fcimb-12-998748-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26d3/9530275/6383d4be9c65/fcimb-12-998748-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26d3/9530275/fbfcc709e0b1/fcimb-12-998748-g003.jpg

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