基于基因组规模建模和系统代谢工程的海氏肠杆菌 1,3-丙二醇生产。
Genome-Scale Modeling and Systems Metabolic Engineering of Vibrio natriegens for the Production of 1,3-Propanediol.
机构信息
Key Laboratory for Industrial Biocatalysis (Ministry of Education), Department of Chemical Engineering, Tsinghua University, Beijing, China.
Tsinghua Innovation Center in Dongguan, Dongguan, China.
出版信息
Methods Mol Biol. 2023;2553:209-220. doi: 10.1007/978-1-0716-2617-7_11.
The fastest-growing bacterium Vibrio natriegens is a highly promising next-generation workhorse for molecular biology and industrial biotechnology. In this work, we described the workflows for developing genome-scale metabolic models and genome-editing protocols for engineering Vibrio natriegens. A case study for metabolic engineering of Vibrio natriegens for the production of 1,3-propanediol was also presented.
增长最快的细菌Vibrio natriegens 是分子生物学和工业生物技术极具前景的下一代主力。在这项工作中，我们描述了开发基因组规模代谢模型和基因组编辑协议以工程化Vibrio natriegens 的工作流程。还介绍了用于生产 1,3-丙二醇的Vibrio natriegens 代谢工程的案例研究。
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