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[家兔个体发育过程中丘脑伤害感受系统的电生理分析]

[Electrophysiologic analysis of the nociceptive system of the thalamus in the ontogenesis of the rabbit].

作者信息

Butkevich I P, Malysheva V V, Kassil' V G

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1987 May;73(5):630-6.

PMID:3622826
Abstract

In acute experiments in rabbits, characteristics of the parafascicular complex EPs in response to peripheral nociceptive stimulation revealed that the waveform of the EP changes during the ontogenesis: from a marked variability in newborn rabbits to a stable biphasic positive-negative potential in adult rabbits. During the postnatal period the magnitudes of the latency and duration of phases of the EPs decrease. "Critical periods" in the formation of the parafascicular complex have been discovered. The 1st period (7-8 days of age) is characterized by the largest amplitude and the shortest duration; the 2nd period (18-40-50 days) involves a stable form of the basic negative long phase. It has been established that, during the ontogenesis, the threshold of the nociceptive response rose.

摘要

在对家兔进行的急性实验中,束旁复合体诱发电位(EP)对外周伤害性刺激的反应特征显示,诱发电位的波形在个体发育过程中会发生变化:从新生兔的明显多变,到成年兔稳定的双相正负电位。在出生后的时期,诱发电位各阶段的潜伏期和持续时间会缩短。已经发现了束旁复合体形成过程中的“关键期”。第一个时期(7 - 8日龄)的特点是振幅最大、持续时间最短;第二个时期(18 - 40 - 50日龄)涉及基本负向长时相的稳定形式。已经确定,在个体发育过程中,伤害性反应的阈值会升高。

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