Department of Urology, Yixing Traditional Chinese Medicine Hospital, Yixing 214200, China.
Department of Urology, Affiliated Hospital of Jiangsu University-Yixing Hospital, Yixing 214200, China.
Cells. 2022 Sep 30;11(19):3075. doi: 10.3390/cells11193075.
The calcium-sensing receptor (CaSR), a G-protein-coupled receptor (GPCR), is a cell-surface-located receptor that can induce highly diffusible messengers (IP3, Ca, cAMP) in the cytoplasm to activate various cellular responses. Recently, it has also been suggested that the CaSR mediates the intracellular communications between the endoplasmic reticulum (ER), mitochondria, nucleus, protease/proteasome, and autophagy-lysosome, which are involved in related cardiovascular diseases. The complex intracellular signaling of this receptor challenges it as a valuable therapeutic target. It is, therefore, necessary to understand the mechanisms behind the signaling characteristics of this receptor in intracellular communication. This review provides an overview of the recent research progress on the various regulatory mechanisms of the CaSR in related cardiovascular diseases and the heart-kidney interaction; the associated common causes are also discussed.
钙敏感受体（CaSR）是一种 G 蛋白偶联受体（GPCR），位于细胞表面，能够在细胞质中诱导高度扩散的信使（IP3、Ca、cAMP），从而激活各种细胞反应。最近，也有人提出 CaSR 介导内质网（ER）、线粒体、核、蛋白酶/蛋白酶体和自噬溶酶体之间的细胞内通讯，这些通讯与相关心血管疾病有关。该受体的复杂细胞内信号转导使其成为一个有价值的治疗靶点。因此，有必要了解该受体在细胞内通讯中的信号特征的背后机制。这篇综述概述了钙敏感受体在相关心血管疾病和心肾相互作用中的各种调节机制的最新研究进展，并讨论了相关的常见原因。
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