JAK-STAT 通路 30 年：学无止境，任重道远。
The JAK-STAT pathway at 30: Much learned, much more to do.
机构信息
Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
出版信息
Cell. 2022 Oct 13;185(21):3857-3876. doi: 10.1016/j.cell.2022.09.023.
Abstract
The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway arose from investigations of how cells respond to interferons (IFNs), revealing a paradigm in cell signaling conserved from slime molds to mammals. These discoveries revealed mechanisms underlying rapid gene expression mediated by a wide variety of extracellular polypeptides including cytokines, interleukins, and related factors. This knowledge has provided numerous insights into human disease, from immune deficiencies to cancer, and was rapidly translated to new drugs for autoimmune, allergic, and infectious diseases, including COVID-19. Despite these advances, major challenges and opportunities remain.
摘要
Janus 激酶（JAK）-信号转导子和转录激活子（STAT）通路的发现源于对细胞如何响应干扰素（IFNs）的研究，揭示了从黏菌到哺乳动物中保守的细胞信号传导范例。这些发现揭示了广泛的细胞外多肽（包括细胞因子、白细胞介素和相关因子）介导的快速基因表达的机制。这些知识为从免疫缺陷到癌症等人类疾病提供了许多深入的了解，并迅速转化为用于自身免疫、过敏和传染病（包括 COVID-19）的新药。尽管取得了这些进展，但仍存在重大挑战和机遇。
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