在头颈部鳞状细胞癌中对预后和免疫浸润作用的综合分析。
Comprehensive Analysis of the Role of on Prognosis and Immune Infiltration in Head and Neck Squamous Cell Carcinoma.
机构信息
Suzhou Stomatological Hospital, Suzhou 215000, China.
Department of Stomatology, Wuxi No.2 People's Hospital, Wuxi 214000, China.
出版信息
Anal Cell Pathol (Amst). 2022 Sep 19;2022:2371057. doi: 10.1155/2022/2371057. eCollection 2022.
BACKGROUND
is upregulated in various cancer types and promotes proliferation, invasion, and metabolism. However, its role in the prognosis and immune regulation of head and neck squamous cell carcinoma (HNSCC) is still obscure. This study is aimed at exploring the prognostic and immunotherapeutic potential of in HNSCC.
METHODS
All data were downloaded from TCGA database and integrated via R software. expression was evaluated using R software, TIMER, CPTAC, and HPA databases. The association between expression and clinicopathologic characteristics was assessed by R software. The effect of on survival was analyzed by R software and Kaplan-Meier Plotter. Genomic alterations in were investigated using the cBioPortal database. Coexpression of was studied using LinkedOmics and STRING, and enrichment analyses were performed with R software. The relationship between expression and immune infiltration was determined using TIMER and TISIDB databases. Immune checkpoints and ESTIMATE score were analyzed via the SangerBox database.
RESULTS
expression was upregulated in HNSCC tissues compared to normal tissues. It was significantly related to TNM stage, histological grade, and alcohol history. High expression was associated with poor prognosis in HNSCC. Coexpression analysis indicated that mostly participated in the HIF-1 signaling pathway and glycolysis. Furthermore, expression strongly correlated with tumor-infiltrating lymphocytes in HNSCC.
CONCLUSION
could serve as a potential prognostic biomarker for tumor immune infiltration in HNSCC.
背景
在多种癌症类型中上调，并促进增殖、侵袭和代谢。然而，其在头颈部鳞状细胞癌（HNSCC）中的预后和免疫调节作用尚不清楚。本研究旨在探讨在 HNSCC 中的预后和免疫治疗潜力。
方法
所有数据均从 TCGA 数据库下载，并通过 R 软件进行整合。使用 R 软件、TIMER、CPTAC 和 HPA 数据库评估表达。使用 R 软件评估表达与临床病理特征的关联。使用 R 软件和 Kaplan-Meier Plotter 分析对生存的影响。使用 cBioPortal 数据库研究中的基因组改变。使用 LinkedOmics 和 STRING 研究的共表达，并使用 R 软件进行富集分析。使用 TIMER 和 TISIDB 数据库确定与免疫浸润的关系。通过 SangerBox 数据库分析免疫检查点和 ESTIMATE 评分。
结果
与正常组织相比，HNSCC 组织中表达上调。它与 TNM 分期、组织学分级和酒精史显著相关。高表达与 HNSCC 的不良预后相关。共表达分析表明，主要参与 HIF-1 信号通路和糖酵解。此外，在 HNSCC 中，表达与肿瘤浸润淋巴细胞强烈相关。
结论
可能成为 HNSCC 肿瘤免疫浸润的潜在预后生物标志物。
Zotero 插件