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一例妊娠期微小病变肾病——早期诊断及使用皮质类固醇激素的益处

A case of minimal change disease during pregnancy - benefits of early diagnosis and use of corticosteroids.

作者信息

Sagar Priyanka S, Fischer Eddy, Gangadharan Komala Muralikrishna, Bose Bhadran

机构信息

Department of Renal Medicine, Nepean Hospital, Penrith, NSW, Australia.

出版信息

Obstet Med. 2022 Sep;15(3):198-200. doi: 10.1177/1753495X21990214. Epub 2021 Feb 9.

Abstract

Nephrotic syndrome presenting in pregnancy is rare and poses a diagnostic and therapeutic challenge. Timing of renal biopsy is important given the increased risk of bleeding and miscarriage, and the choice of immunosuppression is limited due to the teratogenicity profiles of standard drugs. We report and discuss a case of minimal change disease diagnosed by renal biopsy during early pregnancy and treated with corticosteroids throughout the pregnancy. Prompt diagnosis and treatment of glomerular disease in pregnancy are vital to prevent poor maternal and fetal outcomes.

摘要

妊娠期间出现的肾病综合征较为罕见,会带来诊断和治疗方面的挑战。鉴于出血和流产风险增加,肾活检的时机很重要,而且由于标准药物的致畸性,免疫抑制的选择也受到限制。我们报告并讨论了一例在妊娠早期经肾活检诊断为微小病变病并在整个孕期接受皮质类固醇治疗的病例。对妊娠期肾小球疾病进行及时诊断和治疗对于预防不良母婴结局至关重要。

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