Promotes Endometrial Stromal Cell Proliferation and Invasion in Endometriosis via the /TRIM59 Axis.

Long non-coding RNA (LncRNA) emerges as a regulator in various diseases, including endometriosis (EM). This study aims to uncover the role of ()-mediated competing endogenous RNA mechanism in endometrial stromal cell (ESC) proliferation and invasion in EM by regulating /TRIM59. ESCs were isolated from eutopic and ectopic endometrial tissues, followed by the determination of Cytokeratin 19 and Vimentin expressions in cells. Then, expressions of , , and tripartite motif-containing 59 (TRIM59) in tissues and cells were determined by real-time quantitative polymerase chain reaction or Western blot assay, and cell proliferation and invasion were evaluated by cell counting kit-8 and transwell assays. After that, the subcellular localization of and binding of to or TRIM59 were analyzed. was upregulated in ectopic endometrial tissues and ectopic ESCs (Ect-ESCs). Silencing suppressed Ect-ESC proliferation and invasion. inhibited to promote TRIM59 expression. downregulation or TRIM59 overexpression both reversed the effects of silencing on Ect-ESC proliferation and invasion. In summary, our findings suggested that facilitated Ect-ESC proliferation and invasion by inhibiting and promoting TRIM59.