一种调节细胞铁死亡的 NADPH 传感器。
An NADPH sensor that regulates cell ferroptosis.
机构信息
Department of Clinical Laboratory, Guangzhou Panyu Sixth People's Hospital, 511442, Guangzhou, China.
Department of Hepatobiliary Surgery, Shunde Hospital of Southern Medical University (The First People's Hospital of Shunde), 528300, Foshan, Guangdong , PR China.
出版信息
J Transl Med. 2022 Oct 20;20(1):474. doi: 10.1186/s12967-022-03658-3.
Ferroptosis is a new form of programmed cell death, which achieved great breakthroughs in cell biology during past decade. However, the regulation of ferroptosis is yet to be identified thoroughly. The latest study published on Nature cell biology by Nguyen and colleagues found a new NADPH sensor, MARCHF6 an E3 ubiquitin ligase, mediates ferroptosis in tumor growth and animal development. This finding provides a novel insight into ubiquitin system and energy metabolism in regulation of ferroptosis, which may open up new avenues for tumor treatment.
铁死亡是一种新的细胞程序性死亡形式，在过去十年的细胞生物学中取得了重大突破。然而，铁死亡的调控机制尚未被完全阐明。Nguyen 及其同事最近在《自然细胞生物学》上发表的研究发现，一种新的 NADPH 传感器 MARCHF6（一种 E3 泛素连接酶）介导了肿瘤生长和动物发育中的铁死亡。这一发现为泛素系统和能量代谢在铁死亡调控中的作用提供了新的见解，可能为肿瘤治疗开辟新的途径。
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